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Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective trea...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347845/ https://www.ncbi.nlm.nih.gov/pubmed/34361701 http://dx.doi.org/10.3390/molecules26154547 |
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author | Moon, Hyejin Ko, Myoungsil Park, Yujin Kim, Jeonguk Yoon, Dowon Lee, Eunjoohwang Lee, Taehoon Kim, Hakwon |
author_facet | Moon, Hyejin Ko, Myoungsil Park, Yujin Kim, Jeonguk Yoon, Dowon Lee, Eunjoohwang Lee, Taehoon Kim, Hakwon |
author_sort | Moon, Hyejin |
collection | PubMed |
description | Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ(8(14))-ergostenol, was discovered, and its glycosides were synthesized and found to be more efficient in terms of synthesis or anti-inflammatory activity than either spinasterol or 5,6-dihydroergosterol is. Among these synthetic glycosides, galactosyl ergostenol inhibited the expression of inflammatory mediators in TNF-α-stimulated FLS and TNF-α-induced MMPs and collagen type II A1 degradation in human chondrocytes. These results suggest the new galactosyl ergostenol as a treatment candidate for arthritis. |
format | Online Article Text |
id | pubmed-8347845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83478452021-08-08 Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase Moon, Hyejin Ko, Myoungsil Park, Yujin Kim, Jeonguk Yoon, Dowon Lee, Eunjoohwang Lee, Taehoon Kim, Hakwon Molecules Communication Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ(8(14))-ergostenol, was discovered, and its glycosides were synthesized and found to be more efficient in terms of synthesis or anti-inflammatory activity than either spinasterol or 5,6-dihydroergosterol is. Among these synthetic glycosides, galactosyl ergostenol inhibited the expression of inflammatory mediators in TNF-α-stimulated FLS and TNF-α-induced MMPs and collagen type II A1 degradation in human chondrocytes. These results suggest the new galactosyl ergostenol as a treatment candidate for arthritis. MDPI 2021-07-28 /pmc/articles/PMC8347845/ /pubmed/34361701 http://dx.doi.org/10.3390/molecules26154547 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Moon, Hyejin Ko, Myoungsil Park, Yujin Kim, Jeonguk Yoon, Dowon Lee, Eunjoohwang Lee, Taehoon Kim, Hakwon Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase |
title | Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase |
title_full | Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase |
title_fullStr | Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase |
title_full_unstemmed | Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase |
title_short | Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase |
title_sort | δ(8(14))-ergostenol glycoside derivatives inhibit the expression of inflammatory mediators and matrix metalloproteinase |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347845/ https://www.ncbi.nlm.nih.gov/pubmed/34361701 http://dx.doi.org/10.3390/molecules26154547 |
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