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Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase

Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective trea...

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Autores principales: Moon, Hyejin, Ko, Myoungsil, Park, Yujin, Kim, Jeonguk, Yoon, Dowon, Lee, Eunjoohwang, Lee, Taehoon, Kim, Hakwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347845/
https://www.ncbi.nlm.nih.gov/pubmed/34361701
http://dx.doi.org/10.3390/molecules26154547
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author Moon, Hyejin
Ko, Myoungsil
Park, Yujin
Kim, Jeonguk
Yoon, Dowon
Lee, Eunjoohwang
Lee, Taehoon
Kim, Hakwon
author_facet Moon, Hyejin
Ko, Myoungsil
Park, Yujin
Kim, Jeonguk
Yoon, Dowon
Lee, Eunjoohwang
Lee, Taehoon
Kim, Hakwon
author_sort Moon, Hyejin
collection PubMed
description Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ(8(14))-ergostenol, was discovered, and its glycosides were synthesized and found to be more efficient in terms of synthesis or anti-inflammatory activity than either spinasterol or 5,6-dihydroergosterol is. Among these synthetic glycosides, galactosyl ergostenol inhibited the expression of inflammatory mediators in TNF-α-stimulated FLS and TNF-α-induced MMPs and collagen type II A1 degradation in human chondrocytes. These results suggest the new galactosyl ergostenol as a treatment candidate for arthritis.
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spelling pubmed-83478452021-08-08 Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase Moon, Hyejin Ko, Myoungsil Park, Yujin Kim, Jeonguk Yoon, Dowon Lee, Eunjoohwang Lee, Taehoon Kim, Hakwon Molecules Communication Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ(8(14))-ergostenol, was discovered, and its glycosides were synthesized and found to be more efficient in terms of synthesis or anti-inflammatory activity than either spinasterol or 5,6-dihydroergosterol is. Among these synthetic glycosides, galactosyl ergostenol inhibited the expression of inflammatory mediators in TNF-α-stimulated FLS and TNF-α-induced MMPs and collagen type II A1 degradation in human chondrocytes. These results suggest the new galactosyl ergostenol as a treatment candidate for arthritis. MDPI 2021-07-28 /pmc/articles/PMC8347845/ /pubmed/34361701 http://dx.doi.org/10.3390/molecules26154547 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Moon, Hyejin
Ko, Myoungsil
Park, Yujin
Kim, Jeonguk
Yoon, Dowon
Lee, Eunjoohwang
Lee, Taehoon
Kim, Hakwon
Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
title Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
title_full Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
title_fullStr Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
title_full_unstemmed Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
title_short Δ(8(14))-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
title_sort δ(8(14))-ergostenol glycoside derivatives inhibit the expression of inflammatory mediators and matrix metalloproteinase
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347845/
https://www.ncbi.nlm.nih.gov/pubmed/34361701
http://dx.doi.org/10.3390/molecules26154547
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