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Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease

Extraintestinal cancers are important complications in patients with inflammatory bowel disease (IBD). A limited number of publications are available regarding the association between IBD and urothelial cancer. The primary outcome of our study was the comparison of the prevalence of urothelial cance...

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Autores principales: Caviglia, Gian Paolo, Martini, Giorgio, Armandi, Angelo, Rosso, Chiara, Vernero, Marta, Bugianesi, Elisabetta, Astegiano, Marco, Saracco, Giorgio Maria, Ribaldone, Davide Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347965/
https://www.ncbi.nlm.nih.gov/pubmed/34362041
http://dx.doi.org/10.3390/jcm10153257
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author Caviglia, Gian Paolo
Martini, Giorgio
Armandi, Angelo
Rosso, Chiara
Vernero, Marta
Bugianesi, Elisabetta
Astegiano, Marco
Saracco, Giorgio Maria
Ribaldone, Davide Giuseppe
author_facet Caviglia, Gian Paolo
Martini, Giorgio
Armandi, Angelo
Rosso, Chiara
Vernero, Marta
Bugianesi, Elisabetta
Astegiano, Marco
Saracco, Giorgio Maria
Ribaldone, Davide Giuseppe
author_sort Caviglia, Gian Paolo
collection PubMed
description Extraintestinal cancers are important complications in patients with inflammatory bowel disease (IBD). A limited number of publications are available regarding the association between IBD and urothelial cancer. The primary outcome of our study was the comparison of the prevalence of urothelial cancer in patients with IBD with respect to the prevalence in the general population. Secondary outcomes were the assessment of risk factors for the onset of urothelial cancer in IBD. In a retrospective study we examined the medical records of all patients with a confirmed diagnosis of IBD followed in our clinic between 1978 and 2021. For each of the patients with identified urothelial cancer, more than ten patients without cancer were analyzed. Furthermore, 5739 patients with IBD were analyzed and 24 patients diagnosed with urothelial cancer were identified. The incidence of urothelial cancer, compared with the incidence in the general population, was not significantly different (0.42% vs. 0.42%; p = 0.98). Twenty-three cases were then compared (1 case was discarded due to lack of follow-up data) against 250 controls. During the multivariate analysis, smoking (odds ratio, OR = 8.15; 95% confidence interval, CI = 1.76–37.63; p = 0.007) and male sex (OR = 4.04; 95% CI = 1.29–12.66; p = 0.016) were found as risk factors. In conclusion, patients with IBD have a similar risk of developing urothelial cancer compared to the general population, but males with a history of smoking are at increased risk.
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spelling pubmed-83479652021-08-08 Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease Caviglia, Gian Paolo Martini, Giorgio Armandi, Angelo Rosso, Chiara Vernero, Marta Bugianesi, Elisabetta Astegiano, Marco Saracco, Giorgio Maria Ribaldone, Davide Giuseppe J Clin Med Article Extraintestinal cancers are important complications in patients with inflammatory bowel disease (IBD). A limited number of publications are available regarding the association between IBD and urothelial cancer. The primary outcome of our study was the comparison of the prevalence of urothelial cancer in patients with IBD with respect to the prevalence in the general population. Secondary outcomes were the assessment of risk factors for the onset of urothelial cancer in IBD. In a retrospective study we examined the medical records of all patients with a confirmed diagnosis of IBD followed in our clinic between 1978 and 2021. For each of the patients with identified urothelial cancer, more than ten patients without cancer were analyzed. Furthermore, 5739 patients with IBD were analyzed and 24 patients diagnosed with urothelial cancer were identified. The incidence of urothelial cancer, compared with the incidence in the general population, was not significantly different (0.42% vs. 0.42%; p = 0.98). Twenty-three cases were then compared (1 case was discarded due to lack of follow-up data) against 250 controls. During the multivariate analysis, smoking (odds ratio, OR = 8.15; 95% confidence interval, CI = 1.76–37.63; p = 0.007) and male sex (OR = 4.04; 95% CI = 1.29–12.66; p = 0.016) were found as risk factors. In conclusion, patients with IBD have a similar risk of developing urothelial cancer compared to the general population, but males with a history of smoking are at increased risk. MDPI 2021-07-23 /pmc/articles/PMC8347965/ /pubmed/34362041 http://dx.doi.org/10.3390/jcm10153257 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caviglia, Gian Paolo
Martini, Giorgio
Armandi, Angelo
Rosso, Chiara
Vernero, Marta
Bugianesi, Elisabetta
Astegiano, Marco
Saracco, Giorgio Maria
Ribaldone, Davide Giuseppe
Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease
title Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease
title_full Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease
title_fullStr Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease
title_full_unstemmed Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease
title_short Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease
title_sort risk factors of urothelial cancer in inflammatory bowel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347965/
https://www.ncbi.nlm.nih.gov/pubmed/34362041
http://dx.doi.org/10.3390/jcm10153257
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