Cargando…

Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders

Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these diseases. Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quezada, Elías, Rodríguez-Enríquez, Fernanda, Laguna, Reyes, Cutrín, Elena, Otero, Francisco, Uriarte, Eugenio, Viña, Dolores
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348017/ https://www.ncbi.nlm.nih.gov/pubmed/34361702 http://dx.doi.org/10.3390/molecules26154550

Ejemplares similares

Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans-6-Styrylcoumarin
por: Mellado, Marco, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases
por: Bolognino, Isabella, et al.
Publicado: (2021)

Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds
por: Matos, Maria J., et al.
Publicado: (2015)

Adenosine Receptor Ligands: Coumarin–Chalcone Hybrids as Modulating Agents on the Activity of hARs
por: Vazquez-Rodriguez, Saleta, et al.
Publicado: (2020)

Computational Drug Target Screening through Protein Interaction Profiles
por: Vilar, Santiago, et al.
Publicado: (2016)

Multitarget Therapeutics for Neurodegenerative Diseases
por: Gabr, Moustafa T., et al.
Publicado: (2020)

3-Phenylcoumarin
por: Matos, Maria J., et al.
Publicado: (2012)

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases
por: Vicente-Zurdo, David, et al.
Publicado: (2023)

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases
por: Załuski, Michał, et al.
Publicado: (2023)

Coumarin analogue 3-methyl-7H-furo[3,2-g]chromen-7-one as a possible antiparkinsonian agent
por: Olaya, María del Pilar, et al.
Publicado: (2019)

Multitarget Drug Design, Molecular Docking and PLIF Studies of Novel Tacrine−Coumarin Hybrids for the Treatment of Alzheimer’s Disease
por: Fereidoonnezhad, Masood, et al.
Publicado: (2018)

Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study
por: Takla, Fiby N., et al.
Publicado: (2023)

Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids
por: Fais, Antonella, et al.
Publicado: (2009)

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases
por: Chavarria, Daniel, et al.
Publicado: (2021)

Trending Topics on Coumarin and Its Derivatives in 2020
por: Carneiro, Aitor, et al.
Publicado: (2021)

Curcumin: A Natural Multitarget Treatment for Pancreatic Cancer
por: Sahebkar, Amirhossein
Publicado: (2016)

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation
por: Cores, Ángel, et al.
Publicado: (2021)

3-(4-Methoxybenzoyl)-6-nitrocoumarin
por: Vazquez-Rodriguez, Saleta, et al.
Publicado: (2013)

Multitarget Molecular Hybrids of Cinnamic Acids
por: Peperidou, Aikaterini, et al.
Publicado: (2014)

Synthesis and Vasorelaxant Activity of Nitrate−Coumarin Derivatives
por: Matos, Maria João, et al.
Publicado: (2022)

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer’s and Other Neurodegenerative Diseases
por: Cornec, Anne-Sophie, et al.
Publicado: (2017)

Phytochemical Analysis and Antiproliferative Activity of Ulex gallii Planch. (Fabaceae), a Medicinal Plant from Galicia (Spain)
por: Bada, Lucía, et al.
Publicado: (2023)

Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
por: Cheke, Rameshwar S., et al.
Publicado: (2022)

Soyasapogenol-B as a Potential Multitarget Therapeutic Agent for Neurodegenerative Disorders: Molecular Docking and Dynamics Study
por: Iqbal, Danish, et al.
Publicado: (2022)

Synthesis of a Coumarin-Based Analogue of Schweinfurthin F
por: Schroeder, Chloe M., et al.
Publicado: (2021)

Synthesis of novel coumarin analogues: Investigation of molecular docking interaction of SARS-CoV-2 proteins with natural and synthetic coumarin analogues and their pharmacokinetics studies
por: Chidambaram, Sathishkumar, et al.
Publicado: (2021)

A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders
por: Simeonova, Rumyana, et al.
Publicado: (2021)

Hybridization of Curcumin Analogues with Cinnamic Acid Derivatives as Multi-Target Agents Against Alzheimer’s Disease Targets
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Synthesis and biological evaluation of coumarin-quinone hybrids as multifunctional bioactive agents
por: Pangal, Anees, et al.
Publicado: (2022)

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues
por: Chavarria, Daniel, et al.
Publicado: (2019)

Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells
por: Gkionis, Leonidas, et al.
Publicado: (2020)

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease
por: Chaves, Sílvia, et al.
Publicado: (2020)

Curation and Analysis of Multitargeting Agents for Polypharmacological Modeling
por: Reddy, A. Srinivas, et al.
Publicado: (2014)

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease
por: Marotta, Giambattista, et al.
Publicado: (2020)

Design, Synthesis, and Mechanism of Dihydroartemisinin–Coumarin Hybrids as Potential Anti-Neuroinflammatory Agents
por: Yu, Haonan, et al.
Publicado: (2019)

The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents
por: Shang, Hai, et al.
Publicado: (2022)

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies
por: Huneif, Mohammed A., et al.
Publicado: (2023)

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids
por: Otero, Elver, et al.
Publicado: (2014)

Hydroxy-3-Phenylcoumarins as Multitarget Compounds for Skin Aging Diseases: Synthesis, Molecular Docking and Tyrosinase, Elastase, Collagenase and Hyaluronidase Inhibition, and Sun Protection Factor
por: Pintus, Francesca, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_didtqp6qio2j9m0eckk5cajqbd