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CD39 Regulation and Functions in T Cells
CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment. Here, we first review...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348030/ https://www.ncbi.nlm.nih.gov/pubmed/34360833 http://dx.doi.org/10.3390/ijms22158068 |
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author | Timperi, Eleonora Barnaba, Vincenzo |
author_facet | Timperi, Eleonora Barnaba, Vincenzo |
author_sort | Timperi, Eleonora |
collection | PubMed |
description | CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment. Here, we first review the environmental and genetic factors shaping CD39 expression. Second, we report CD39 functions in the T cell compartment, highlighting its role in regulatory T cells, conventional CD4(+) T cells and CD8(+) T cells. Finally, we compile a list of studies, from preclinical models to clinical trials, which have made essential contributions to the discovery of novel combinatorial approaches in the treatment of cancer. |
format | Online Article Text |
id | pubmed-8348030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83480302021-08-08 CD39 Regulation and Functions in T Cells Timperi, Eleonora Barnaba, Vincenzo Int J Mol Sci Review CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment. Here, we first review the environmental and genetic factors shaping CD39 expression. Second, we report CD39 functions in the T cell compartment, highlighting its role in regulatory T cells, conventional CD4(+) T cells and CD8(+) T cells. Finally, we compile a list of studies, from preclinical models to clinical trials, which have made essential contributions to the discovery of novel combinatorial approaches in the treatment of cancer. MDPI 2021-07-28 /pmc/articles/PMC8348030/ /pubmed/34360833 http://dx.doi.org/10.3390/ijms22158068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Timperi, Eleonora Barnaba, Vincenzo CD39 Regulation and Functions in T Cells |
title | CD39 Regulation and Functions in T Cells |
title_full | CD39 Regulation and Functions in T Cells |
title_fullStr | CD39 Regulation and Functions in T Cells |
title_full_unstemmed | CD39 Regulation and Functions in T Cells |
title_short | CD39 Regulation and Functions in T Cells |
title_sort | cd39 regulation and functions in t cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348030/ https://www.ncbi.nlm.nih.gov/pubmed/34360833 http://dx.doi.org/10.3390/ijms22158068 |
work_keys_str_mv | AT timperieleonora cd39regulationandfunctionsintcells AT barnabavincenzo cd39regulationandfunctionsintcells |