Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine

Fundamental pancreatic β-cell function is to produce and secrete insulin in response to blood glucose levels. However, when β-cells are chronically exposed to hyperglycemia in type 2 diabetes mellitus (T2DM), insulin biosynthesis and secretion are decreased together with reduced expression of insuli...

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Detalles Bibliográficos
Autores principales: Kaneto, Hideaki, Kimura, Tomohiko, Shimoda, Masashi, Obata, Atsushi, Sanada, Junpei, Fushimi, Yoshiro, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348147/
https://www.ncbi.nlm.nih.gov/pubmed/34360682
http://dx.doi.org/10.3390/ijms22157917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348147/
https://www.ncbi.nlm.nih.gov/pubmed/34360682
http://dx.doi.org/10.3390/ijms22157917

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