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Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine
Fundamental pancreatic β-cell function is to produce and secrete insulin in response to blood glucose levels. However, when β-cells are chronically exposed to hyperglycemia in type 2 diabetes mellitus (T2DM), insulin biosynthesis and secretion are decreased together with reduced expression of insuli...
Autores principales: | Kaneto, Hideaki, Kimura, Tomohiko, Shimoda, Masashi, Obata, Atsushi, Sanada, Junpei, Fushimi, Yoshiro, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348147/ https://www.ncbi.nlm.nih.gov/pubmed/34360682 http://dx.doi.org/10.3390/ijms22157917 |
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