Cargando…

Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran

People with beta-thalassemia major are more likely to acquire blood-borne viral infections due to the need for frequent blood transfusions. Of these viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) are of particular importance. In this study, the prevalence of HBV, HCV and their risk fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Mirzaei, G., Shamsasenjan, K., Jafari, B., Bagherizadeh, Y., Sadafzadeh, A., Bannazadeh-Baghi, H., Sadeghi-Deylamdeh, Z., Jafari-Sales, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348174/
https://www.ncbi.nlm.nih.gov/pubmed/34401191
http://dx.doi.org/10.1016/j.nmni.2021.100912
_version_ 1783735274698702848
author Mirzaei, G.
Shamsasenjan, K.
Jafari, B.
Bagherizadeh, Y.
Sadafzadeh, A.
Bannazadeh-Baghi, H.
Sadeghi-Deylamdeh, Z.
Jafari-Sales, A.
author_facet Mirzaei, G.
Shamsasenjan, K.
Jafari, B.
Bagherizadeh, Y.
Sadafzadeh, A.
Bannazadeh-Baghi, H.
Sadeghi-Deylamdeh, Z.
Jafari-Sales, A.
author_sort Mirzaei, G.
collection PubMed
description People with beta-thalassemia major are more likely to acquire blood-borne viral infections due to the need for frequent blood transfusions. Of these viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) are of particular importance. In this study, the prevalence of HBV, HCV and their risk factors in beta-thalassemia major patients in East Azerbaijan province was investigated. The study was descriptive cross-sectional, and 116 beta-thalassemia major patients who received blood in Shahid Ghazi hospital and Children’s hospital in Tabriz city were studied. Data were collected by a questionnaire, and blood samples of patients in terms of serum markers HCV-Ab, HBsAg and HBs-Ab were analyzed by ELISA, and positive HCV-Ab results were confirmed by Real Time-PCR. Then using SPSS software version 22 and with the help of t-tests including Anova T-test, Man-Whitney U test, Independent sample t-test, chi-square and Fisher exact test, Statistical studies were performed. Of the 116 patients studied, no HBsAg positive cases were found. Four patients (3.4%) were positive for HCV-Ab, of which two patients (1.7%) became HCV-RNA positive after Real Time-PCR. There was a significant relationship between HCV-Ab positive and HCV-RNA positive (P = 0.000), blood transfusion intervals (P = 0.043), number of injected blood units (P = 0.001) and duration of blood transfusion (P = 0.006). The prevalence of HCV was lower in patients who started receiving blood after a blood donor screening program. HCV is less prevalent in thalassemia patients in East Azerbaijan province than in some studies in the country and various global statistics. After 1996, the prevalence of HCV in the thalassemia patient population has decreased significantly, and it seems that HCV infections since 1996 have been associated with various factors such as people’s jobs, position, behaviour in society, etc.
format Online
Article
Text
id pubmed-8348174
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83481742021-08-15 Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran Mirzaei, G. Shamsasenjan, K. Jafari, B. Bagherizadeh, Y. Sadafzadeh, A. Bannazadeh-Baghi, H. Sadeghi-Deylamdeh, Z. Jafari-Sales, A. New Microbes New Infect Original Article People with beta-thalassemia major are more likely to acquire blood-borne viral infections due to the need for frequent blood transfusions. Of these viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) are of particular importance. In this study, the prevalence of HBV, HCV and their risk factors in beta-thalassemia major patients in East Azerbaijan province was investigated. The study was descriptive cross-sectional, and 116 beta-thalassemia major patients who received blood in Shahid Ghazi hospital and Children’s hospital in Tabriz city were studied. Data were collected by a questionnaire, and blood samples of patients in terms of serum markers HCV-Ab, HBsAg and HBs-Ab were analyzed by ELISA, and positive HCV-Ab results were confirmed by Real Time-PCR. Then using SPSS software version 22 and with the help of t-tests including Anova T-test, Man-Whitney U test, Independent sample t-test, chi-square and Fisher exact test, Statistical studies were performed. Of the 116 patients studied, no HBsAg positive cases were found. Four patients (3.4%) were positive for HCV-Ab, of which two patients (1.7%) became HCV-RNA positive after Real Time-PCR. There was a significant relationship between HCV-Ab positive and HCV-RNA positive (P = 0.000), blood transfusion intervals (P = 0.043), number of injected blood units (P = 0.001) and duration of blood transfusion (P = 0.006). The prevalence of HCV was lower in patients who started receiving blood after a blood donor screening program. HCV is less prevalent in thalassemia patients in East Azerbaijan province than in some studies in the country and various global statistics. After 1996, the prevalence of HCV in the thalassemia patient population has decreased significantly, and it seems that HCV infections since 1996 have been associated with various factors such as people’s jobs, position, behaviour in society, etc. Elsevier 2021-07-06 /pmc/articles/PMC8348174/ /pubmed/34401191 http://dx.doi.org/10.1016/j.nmni.2021.100912 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Mirzaei, G.
Shamsasenjan, K.
Jafari, B.
Bagherizadeh, Y.
Sadafzadeh, A.
Bannazadeh-Baghi, H.
Sadeghi-Deylamdeh, Z.
Jafari-Sales, A.
Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran
title Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran
title_full Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran
title_fullStr Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran
title_full_unstemmed Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran
title_short Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran
title_sort prevalence of hbv and hcv infection in beta-thalassemia major patients of tabriz city, iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348174/
https://www.ncbi.nlm.nih.gov/pubmed/34401191
http://dx.doi.org/10.1016/j.nmni.2021.100912
work_keys_str_mv AT mirzaeig prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT shamsasenjank prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT jafarib prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT bagherizadehy prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT sadafzadeha prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT bannazadehbaghih prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT sadeghideylamdehz prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran
AT jafarisalesa prevalenceofhbvandhcvinfectioninbetathalassemiamajorpatientsoftabrizcityiran