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An Overview of NO Signaling Pathways in Aging

Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechani...

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Autores principales: Pourbagher-Shahri, Ali Mohammad, Farkhondeh, Tahereh, Talebi, Marjan, Kopustinskiene, Dalia M., Samarghandian, Saeed, Bernatoniene, Jurga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348219/
https://www.ncbi.nlm.nih.gov/pubmed/34361685
http://dx.doi.org/10.3390/molecules26154533
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author Pourbagher-Shahri, Ali Mohammad
Farkhondeh, Tahereh
Talebi, Marjan
Kopustinskiene, Dalia M.
Samarghandian, Saeed
Bernatoniene, Jurga
author_facet Pourbagher-Shahri, Ali Mohammad
Farkhondeh, Tahereh
Talebi, Marjan
Kopustinskiene, Dalia M.
Samarghandian, Saeed
Bernatoniene, Jurga
author_sort Pourbagher-Shahri, Ali Mohammad
collection PubMed
description Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes.
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spelling pubmed-83482192021-08-08 An Overview of NO Signaling Pathways in Aging Pourbagher-Shahri, Ali Mohammad Farkhondeh, Tahereh Talebi, Marjan Kopustinskiene, Dalia M. Samarghandian, Saeed Bernatoniene, Jurga Molecules Review Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes. MDPI 2021-07-27 /pmc/articles/PMC8348219/ /pubmed/34361685 http://dx.doi.org/10.3390/molecules26154533 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pourbagher-Shahri, Ali Mohammad
Farkhondeh, Tahereh
Talebi, Marjan
Kopustinskiene, Dalia M.
Samarghandian, Saeed
Bernatoniene, Jurga
An Overview of NO Signaling Pathways in Aging
title An Overview of NO Signaling Pathways in Aging
title_full An Overview of NO Signaling Pathways in Aging
title_fullStr An Overview of NO Signaling Pathways in Aging
title_full_unstemmed An Overview of NO Signaling Pathways in Aging
title_short An Overview of NO Signaling Pathways in Aging
title_sort overview of no signaling pathways in aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348219/
https://www.ncbi.nlm.nih.gov/pubmed/34361685
http://dx.doi.org/10.3390/molecules26154533
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