Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins

Many poisonous organisms carry small-molecule toxins that alter voltage-gated sodium channel (Na(V)) function. Among these, batrachotoxin (BTX) from Pitohui poison birds and Phyllobates poison frogs stands out because of its lethality and unusual effects on Na(V) function. How these toxin-bearing or...

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Detalles Bibliográficos
Autores principales: Abderemane-Ali, Fayal, Rossen, Nathan D., Kobiela, Megan E., Craig, Robert A., Garrison, Catherine E., Chen, Zhou, Colleran, Claire M., O’Connell, Lauren A., Du Bois, J., Dumbacher, John P., Minor, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348241/
https://www.ncbi.nlm.nih.gov/pubmed/34351379
http://dx.doi.org/10.1085/jgp.202112872

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