Cargando…

Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice

The liver has a most indispensable role in glucose and lipid metabolism where we see some of the most serious worldwide health problems. The serine protease prostasin (PRSS8) cleaves toll-like receptor 4 (TLR4) and regulates hepatic insulin sensitivity under PRSS8 knockout condition. However, liver...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekine, Tetsuo, Takizawa, Soichi, Uchimura, Kohei, Miyazaki, Asako, Tsuchiya, Kyoichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348244/ https://www.ncbi.nlm.nih.gov/pubmed/34361079 http://dx.doi.org/10.3390/ijms22158314

Ejemplares similares

Regulation of Adrenal Aldosterone Production by Serine Protease Prostasin
por: Ko, Takehiro, et al.
Publicado: (2010)

Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals
por: Nakamura, Suguru, et al.
Publicado: (2021)

Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway
por: Ishii, Toshihisa, et al.
Publicado: (2023)

The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling
por: Uchimura, Kohei, et al.
Publicado: (2014)

Prostasin: An Epithelial Sodium Channel Regulator
por: Aggarwal, Shakti, et al.
Publicado: (2013)

Association between preeclampsia and prostasin polymorphism in Pakistani females
por: Ejaz, Saima, et al.
Publicado: (2020)

Ipragliflozin Ameliorates Diabetic Nephropathy Associated with Perirenal Adipose Expansion in Mice
por: Okuma, Hideyuki, et al.
Publicado: (2021)

Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis
por: Selzer-Plon, Joanna, et al.
Publicado: (2009)

Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females
por: Ejaz, Saima, et al.
Publicado: (2021)

Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis
por: Drees, Leonard, et al.
Publicado: (2019)

Prostasin, A Potential Tumor Marker in Ovarian Cancer- A Pilot Study
por: Costa, Fernanda Pires, et al.
Publicado: (2009)

Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase
por: Chai, Andreas C., et al.
Publicado: (2015)

Prostasin regulates PD-L1 expression in human lung cancer cells
por: Chen, Li-Mei, et al.
Publicado: (2021)

Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality
por: Bao, Xue, et al.
Publicado: (2022)

MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice
por: Smolka, Christian, et al.
Publicado: (2021)

PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer
por: Ma, J-x, et al.
Publicado: (2014)

Exosome-Mediated Activation of the Prostasin-Matriptase Serine Protease Cascade in B Lymphoma Cells
por: Chen, Li-Mei, et al.
Publicado: (2023)

High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats
por: Meli, Rosaria, et al.
Publicado: (2013)

Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance
por: Tsuchiya, Kyoichiro, et al.
Publicado: (2013)

Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice
por: Shimizu, Kahori, et al.
Publicado: (2022)

The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer
por: Tamir, Ayala, et al.
Publicado: (2016)

Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish
por: Khandekar, Gauri, et al.
Publicado: (2020)

Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
por: Jiang, Chung-Lin, et al.
Publicado: (2022)

Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation
por: Lai, Chih-Hsin, et al.
Publicado: (2016)

Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner
por: Su, Hui Chen, et al.
Publicado: (2016)

Xylobiose Prevents High-Fat Diet Induced Mice Obesity by Suppressing Mesenteric Fat Deposition and Metabolic Dysregulation
por: Lim, Soo-min, et al.
Publicado: (2018)

Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy
por: Szabo, Roman, et al.
Publicado: (2018)

Blocking High Fat Diet-induced Obesity, Insulin Resistance and Fatty Liver by Overexpression of Il-13 Gene in Mice
por: Darkhal, Parisa, et al.
Publicado: (2015)

Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice
por: Yang, Yan, et al.
Publicado: (2021)

Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2
por: Shiao, Frank, et al.
Publicado: (2017)

Interferon beta overexpression attenuates adipose tissue inflammation and high fat diet-induced obesity and maintains glucose homeostasis
por: Alsaggar, Mohammad, et al.
Publicado: (2016)

Catalpol induces autophagy and attenuates liver steatosis in ob/ob and high-fat diet-induced obese mice
por: Ren, Huihui, et al.
Publicado: (2019)

Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction
por: Kim, Yo Na, et al.
Publicado: (2021)

Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice
por: Mori, Kentaro, et al.
Publicado: (2023)

A Low-Fat/Sucrose Diet Rich in Complex Carbohydrates Reverses High-Fat/Sucrose Diet-Induced Corneal Dysregulation
por: Akowuah, Prince K., et al.
Publicado: (2023)

Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane
por: Lai, Chih-Hsin, et al.
Publicado: (2016)

Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice
por: Getiye, Yohannes, et al.
Publicado: (2022)

Sleeve gastrectomy attenuates high fat diet-induced non-alcoholic fatty liver disease
por: Pei, Erli, et al.
Publicado: (2018)

Ethanolic Extract of Taheebo Attenuates Increase in Body Weight and Fatty Liver in Mice Fed a High-Fat Diet
por: Choi, Won Hee, et al.
Publicado: (2014)

Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice
por: Mu, Hongna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dkk11hi3qje3miri438ksht7d6