Intrinsically disordered electronegative clusters improve stability and binding specificity of RNA-binding proteins

RNA-binding proteins play crucial roles in various cellular functions and contain abundant disordered protein regions. The disordered regions in RNA-binding proteins are rich in repetitive sequences, such as poly-K/R, poly-N/Q, poly-A, and poly-G residues. Our bioinformatic analysis identified a lar...

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Detalles Bibliográficos
Autores principales: Zaharias, Steve, Zhang, Zihan, Davis, Kenneth, Fargason, Talia, Cashman, Derek, Yu, Tao, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348266/
https://www.ncbi.nlm.nih.gov/pubmed/34246632
http://dx.doi.org/10.1016/j.jbc.2021.100945

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