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Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques

INTRODUCTION: cancer is a major cause of death in the world. The purpose of this study is to evaluate the epidemiological, clinical, therapeutic and prognostic features of cancers of the pancreas (CP) at the National Hospital and University Center of Cotonou. METHODS: we conducted a cross-sectional...

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Autores principales: Kpossou, Aboudou Raïmi, Gbessi, Dansou Gaspard, Gnangnon, Freddy Houéhanou Rodrigue, Ba Boukari, Meissarath Modoukpè, Vignon, Rodolph Koffi, Sokpon, Comlan N´déhougbéa Martin, Sehonou, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348281/
https://www.ncbi.nlm.nih.gov/pubmed/34394809
http://dx.doi.org/10.11604/pamj.2021.39.18.26261
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author Kpossou, Aboudou Raïmi
Gbessi, Dansou Gaspard
Gnangnon, Freddy Houéhanou Rodrigue
Ba Boukari, Meissarath Modoukpè
Vignon, Rodolph Koffi
Sokpon, Comlan N´déhougbéa Martin
Sehonou, Jean
author_facet Kpossou, Aboudou Raïmi
Gbessi, Dansou Gaspard
Gnangnon, Freddy Houéhanou Rodrigue
Ba Boukari, Meissarath Modoukpè
Vignon, Rodolph Koffi
Sokpon, Comlan N´déhougbéa Martin
Sehonou, Jean
author_sort Kpossou, Aboudou Raïmi
collection PubMed
description INTRODUCTION: cancer is a major cause of death in the world. The purpose of this study is to evaluate the epidemiological, clinical, therapeutic and prognostic features of cancers of the pancreas (CP) at the National Hospital and University Center of Cotonou. METHODS: we conducted a cross-sectional descriptive and analytical study with a prospective and retrospective data collection over a period of ten years, from 1 October 2009 to 31 October 2019. RESULTS: out of 15.102 hospitalizations, we identified 72 cases of CP, reflecting a hospitalization rate of 0.5%. The average age of patients was 59 years. The sex-ratio (H/F) was 1.5. The main reason for consultation was abdominal pain. More than half (51.4%) of patients had metastatic tumor at the time of diagnosis. Histological evidence of adenocarcinoma was only reported in 15.1% of cases. The rate of operable patients was 37.5% while the rate of resectable patients was 2.7%. Palliative chemotherapy was given to 13.9% of patients. The average cost of treatment was 955.882,4 FCFA (23.9 times the Guaranteed Interprofessional Minimum Wage in Benin). Median overall survival was 6 months. Mortality rate was 86.9% (53/61), survival rate at one year was 31.4%, and zero at five years. Palliative surgery (p = 0.021) and chemotherapy (p = 0.023) improved patient survival. CONCLUSION: cancer of the pancreas, due to its non-specific signs and insidious outcome, is often diagnosed at a late stage. A metastatic tumor and the limited individual and institutional therapeutic possibilities lead to more pejorative prognosis.
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spelling pubmed-83482812021-08-13 Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques Kpossou, Aboudou Raïmi Gbessi, Dansou Gaspard Gnangnon, Freddy Houéhanou Rodrigue Ba Boukari, Meissarath Modoukpè Vignon, Rodolph Koffi Sokpon, Comlan N´déhougbéa Martin Sehonou, Jean Pan Afr Med J Research INTRODUCTION: cancer is a major cause of death in the world. The purpose of this study is to evaluate the epidemiological, clinical, therapeutic and prognostic features of cancers of the pancreas (CP) at the National Hospital and University Center of Cotonou. METHODS: we conducted a cross-sectional descriptive and analytical study with a prospective and retrospective data collection over a period of ten years, from 1 October 2009 to 31 October 2019. RESULTS: out of 15.102 hospitalizations, we identified 72 cases of CP, reflecting a hospitalization rate of 0.5%. The average age of patients was 59 years. The sex-ratio (H/F) was 1.5. The main reason for consultation was abdominal pain. More than half (51.4%) of patients had metastatic tumor at the time of diagnosis. Histological evidence of adenocarcinoma was only reported in 15.1% of cases. The rate of operable patients was 37.5% while the rate of resectable patients was 2.7%. Palliative chemotherapy was given to 13.9% of patients. The average cost of treatment was 955.882,4 FCFA (23.9 times the Guaranteed Interprofessional Minimum Wage in Benin). Median overall survival was 6 months. Mortality rate was 86.9% (53/61), survival rate at one year was 31.4%, and zero at five years. Palliative surgery (p = 0.021) and chemotherapy (p = 0.023) improved patient survival. CONCLUSION: cancer of the pancreas, due to its non-specific signs and insidious outcome, is often diagnosed at a late stage. A metastatic tumor and the limited individual and institutional therapeutic possibilities lead to more pejorative prognosis. The African Field Epidemiology Network 2021-05-06 /pmc/articles/PMC8348281/ /pubmed/34394809 http://dx.doi.org/10.11604/pamj.2021.39.18.26261 Text en Copyright: Aboudou Raïmi Kpossou et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Kpossou, Aboudou Raïmi
Gbessi, Dansou Gaspard
Gnangnon, Freddy Houéhanou Rodrigue
Ba Boukari, Meissarath Modoukpè
Vignon, Rodolph Koffi
Sokpon, Comlan N´déhougbéa Martin
Sehonou, Jean
Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
title Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
title_full Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
title_fullStr Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
title_full_unstemmed Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
title_short Cancers du pancréas au Centre National Hospitalier Universitaire de Cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
title_sort cancers du pancréas au centre national hospitalier universitaire de cotonou: aspects épidémiologiques, diagnostiques, thérapeutiques et pronostiques
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348281/
https://www.ncbi.nlm.nih.gov/pubmed/34394809
http://dx.doi.org/10.11604/pamj.2021.39.18.26261
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