Cargando…
Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells
Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leak...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348289/ https://www.ncbi.nlm.nih.gov/pubmed/34361114 http://dx.doi.org/10.3390/ijms22158349 |
_version_ | 1783735303308050432 |
---|---|
author | Verna, Giulio Liso, Marina Cavalcanti, Elisabetta Bianco, Giusy Di Sarno, Veronica Santino, Angelo Campiglia, Pietro Chieppa, Marcello |
author_facet | Verna, Giulio Liso, Marina Cavalcanti, Elisabetta Bianco, Giusy Di Sarno, Veronica Santino, Angelo Campiglia, Pietro Chieppa, Marcello |
author_sort | Verna, Giulio |
collection | PubMed |
description | Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1). |
format | Online Article Text |
id | pubmed-8348289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83482892021-08-08 Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells Verna, Giulio Liso, Marina Cavalcanti, Elisabetta Bianco, Giusy Di Sarno, Veronica Santino, Angelo Campiglia, Pietro Chieppa, Marcello Int J Mol Sci Article Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1). MDPI 2021-08-03 /pmc/articles/PMC8348289/ /pubmed/34361114 http://dx.doi.org/10.3390/ijms22158349 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Verna, Giulio Liso, Marina Cavalcanti, Elisabetta Bianco, Giusy Di Sarno, Veronica Santino, Angelo Campiglia, Pietro Chieppa, Marcello Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells |
title | Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells |
title_full | Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells |
title_fullStr | Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells |
title_full_unstemmed | Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells |
title_short | Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells |
title_sort | quercetin administration suppresses the cytokine storm in myeloid and plasmacytoid dendritic cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348289/ https://www.ncbi.nlm.nih.gov/pubmed/34361114 http://dx.doi.org/10.3390/ijms22158349 |
work_keys_str_mv | AT vernagiulio quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT lisomarina quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT cavalcantielisabetta quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT biancogiusy quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT disarnoveronica quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT santinoangelo quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT campigliapietro quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells AT chieppamarcello quercetinadministrationsuppressesthecytokinestorminmyeloidandplasmacytoiddendriticcells |