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Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)

The thrombin binding aptamer (TBA) is a promising nucleic acid-based anticoagulant. We studied the effects of chemical modifications, such as dendrimer Trebler and NHS carboxy group, on TBA with respect to its structures and thrombin binding affinity. The two dendrimer modifications were incorporate...

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Detalles Bibliográficos
Autores principales:	Valsangkar, Vibhav, Vangaveti, Sweta, Lee, Goh Woon, Fahssi, Walid M., Awan, Waqas S., Huang, Yicheng, Chen, Alan A., Sheng, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348300/ https://www.ncbi.nlm.nih.gov/pubmed/34361773 http://dx.doi.org/10.3390/molecules26154620

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