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Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution
Adaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars expand, a lack of oxygen results in the activation of the hypoxia response, promoting cell...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348404/ https://www.ncbi.nlm.nih.gov/pubmed/34361103 http://dx.doi.org/10.3390/ijms22158335 |
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author | Romero, Yair Aquino-Gálvez, Arnoldo |
author_facet | Romero, Yair Aquino-Gálvez, Arnoldo |
author_sort | Romero, Yair |
collection | PubMed |
description | Adaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars expand, a lack of oxygen results in the activation of the hypoxia response, promoting cell survival even during chronic conditions. The role of hypoxia-inducible factors (HIFs) as master regulators of this adaptation is crucial in both lung cancer and idiopathic pulmonary fibrosis, which have shown the active transcriptional signature of this pathway. Emerging evidence suggests that interconnected feedback loops such as metabolic changes, fibroblast differentiation or extracellular matrix remodeling contribute to HIF overactivation, making it an irreversible phenomenon. This review will focus on the role of HIF signaling and its possible overlapping in order to identify new opportunities in therapy and regeneration. |
format | Online Article Text |
id | pubmed-8348404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83484042021-08-08 Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution Romero, Yair Aquino-Gálvez, Arnoldo Int J Mol Sci Review Adaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars expand, a lack of oxygen results in the activation of the hypoxia response, promoting cell survival even during chronic conditions. The role of hypoxia-inducible factors (HIFs) as master regulators of this adaptation is crucial in both lung cancer and idiopathic pulmonary fibrosis, which have shown the active transcriptional signature of this pathway. Emerging evidence suggests that interconnected feedback loops such as metabolic changes, fibroblast differentiation or extracellular matrix remodeling contribute to HIF overactivation, making it an irreversible phenomenon. This review will focus on the role of HIF signaling and its possible overlapping in order to identify new opportunities in therapy and regeneration. MDPI 2021-08-03 /pmc/articles/PMC8348404/ /pubmed/34361103 http://dx.doi.org/10.3390/ijms22158335 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Romero, Yair Aquino-Gálvez, Arnoldo Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
title | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
title_full | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
title_fullStr | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
title_full_unstemmed | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
title_short | Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution |
title_sort | hypoxia in cancer and fibrosis: part of the problem and part of the solution |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348404/ https://www.ncbi.nlm.nih.gov/pubmed/34361103 http://dx.doi.org/10.3390/ijms22158335 |
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