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Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study

Background: We sought to determine if there was a difference in the longitudinal inflammatory response measured by white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), and ferritin levels between the first and the second COVID-19 wave of ICU patients. Methods: In a single-cen...

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Autores principales: Szakmany, Tamas, Tuckwell, William, Harte, Elsa, Wetherall, Nick, Ramachandran, Saraswathi, Price, Shannon, Breen, Henry, Killick, Charlotte, Cheema, Yusuf, King, Charles, Richards, Owen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348515/
https://www.ncbi.nlm.nih.gov/pubmed/34362074
http://dx.doi.org/10.3390/jcm10153290
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author Szakmany, Tamas
Tuckwell, William
Harte, Elsa
Wetherall, Nick
Ramachandran, Saraswathi
Price, Shannon
Breen, Henry
Killick, Charlotte
Cheema, Yusuf
King, Charles
Richards, Owen
author_facet Szakmany, Tamas
Tuckwell, William
Harte, Elsa
Wetherall, Nick
Ramachandran, Saraswathi
Price, Shannon
Breen, Henry
Killick, Charlotte
Cheema, Yusuf
King, Charles
Richards, Owen
author_sort Szakmany, Tamas
collection PubMed
description Background: We sought to determine if there was a difference in the longitudinal inflammatory response measured by white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), and ferritin levels between the first and the second COVID-19 wave of ICU patients. Methods: In a single-center retrospective observational study, ICU patients were enrolled during the first and second waves of the COVID-19 pandemic. Data were collected on patient demographics, comorbidities, laboratory results, management strategies, and complications during the ICU stay. The inflammatory response was evaluated using WBC count, CRP, PCT, and Ferritin levels on the day of admission until Day 28, respectively. Organ dysfunction was measured by the SOFA score. Results: 65 patients were admitted during the first and 113 patients during the second wave. WBC and ferritin levels were higher in the second wave. CRP and PCT showed markedly different longitudinal kinetics up until day 28 of ICU stay between the first and second wave, with significantly lower levels in the second wave. Steroid and immunomodulatory therapy use was significantly greater in the second wave. Mortality was similar in both waves. Conclusions: We found that there was a significantly reduced inflammatory response in the second wave, which is likely to be attributable to the more widespread use of immunomodulatory therapies.
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spelling pubmed-83485152021-08-08 Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study Szakmany, Tamas Tuckwell, William Harte, Elsa Wetherall, Nick Ramachandran, Saraswathi Price, Shannon Breen, Henry Killick, Charlotte Cheema, Yusuf King, Charles Richards, Owen J Clin Med Article Background: We sought to determine if there was a difference in the longitudinal inflammatory response measured by white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), and ferritin levels between the first and the second COVID-19 wave of ICU patients. Methods: In a single-center retrospective observational study, ICU patients were enrolled during the first and second waves of the COVID-19 pandemic. Data were collected on patient demographics, comorbidities, laboratory results, management strategies, and complications during the ICU stay. The inflammatory response was evaluated using WBC count, CRP, PCT, and Ferritin levels on the day of admission until Day 28, respectively. Organ dysfunction was measured by the SOFA score. Results: 65 patients were admitted during the first and 113 patients during the second wave. WBC and ferritin levels were higher in the second wave. CRP and PCT showed markedly different longitudinal kinetics up until day 28 of ICU stay between the first and second wave, with significantly lower levels in the second wave. Steroid and immunomodulatory therapy use was significantly greater in the second wave. Mortality was similar in both waves. Conclusions: We found that there was a significantly reduced inflammatory response in the second wave, which is likely to be attributable to the more widespread use of immunomodulatory therapies. MDPI 2021-07-26 /pmc/articles/PMC8348515/ /pubmed/34362074 http://dx.doi.org/10.3390/jcm10153290 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szakmany, Tamas
Tuckwell, William
Harte, Elsa
Wetherall, Nick
Ramachandran, Saraswathi
Price, Shannon
Breen, Henry
Killick, Charlotte
Cheema, Yusuf
King, Charles
Richards, Owen
Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study
title Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study
title_full Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study
title_fullStr Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study
title_full_unstemmed Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study
title_short Differences in Inflammatory Marker Kinetics between the First and Second Wave of COVID-19 Patients Admitted to the ICU: A Retrospective, Single-Center Study
title_sort differences in inflammatory marker kinetics between the first and second wave of covid-19 patients admitted to the icu: a retrospective, single-center study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348515/
https://www.ncbi.nlm.nih.gov/pubmed/34362074
http://dx.doi.org/10.3390/jcm10153290
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