Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?

Still’s disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. We present here a personal vision of what can link these two diseases, taking up their concepts at their beginning....

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Detalles Bibliográficos
Autores principales: Dusser, Perrine, Koné-Paut, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348569/
https://www.ncbi.nlm.nih.gov/pubmed/34362028
http://dx.doi.org/10.3390/jcm10153244
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author Dusser, Perrine
Koné-Paut, Isabelle
author_facet Dusser, Perrine
Koné-Paut, Isabelle
author_sort Dusser, Perrine
collection PubMed
description Still’s disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. We present here a personal vision of what can link these two diseases, taking up their concepts at their beginning. By their many clinical and physiopathological similarities, we conclude that they constitute a common spectrum whose fate is modified by subtle differences in terms of adaptive response that could, in part, be driven by genetic factors.
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spelling pubmed-83485692021-08-08 Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease? Dusser, Perrine Koné-Paut, Isabelle J Clin Med Review Still’s disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. We present here a personal vision of what can link these two diseases, taking up their concepts at their beginning. By their many clinical and physiopathological similarities, we conclude that they constitute a common spectrum whose fate is modified by subtle differences in terms of adaptive response that could, in part, be driven by genetic factors. MDPI 2021-07-23 /pmc/articles/PMC8348569/ /pubmed/34362028 http://dx.doi.org/10.3390/jcm10153244 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dusser, Perrine
Koné-Paut, Isabelle
Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?
title Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?
title_full Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?
title_fullStr Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?
title_full_unstemmed Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?
title_short Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?
title_sort still’s disease in the constellation of hyperinflammatory syndromes: a link with kawasaki disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348569/
https://www.ncbi.nlm.nih.gov/pubmed/34362028
http://dx.doi.org/10.3390/jcm10153244
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