Cargando…
Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal gluco...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348675/ https://www.ncbi.nlm.nih.gov/pubmed/34362033 http://dx.doi.org/10.3390/jcm10153251 |
_version_ | 1783735397865488384 |
---|---|
author | Gagliardino, Juan J. Salazar, Martin R. Espeche, Walter G. Chapasian, Paula E. Tolosa Gomez Garizoain, Daniela Olano, Ricardo D. Stavile, Rodolfo N. Balbín, Eduardo Martinez, Camilo Sisnieguez, Betty C. Leiva Sisnieguez, Carlos E. Leiva Carbajal, Horacio A. |
author_facet | Gagliardino, Juan J. Salazar, Martin R. Espeche, Walter G. Chapasian, Paula E. Tolosa Gomez Garizoain, Daniela Olano, Ricardo D. Stavile, Rodolfo N. Balbín, Eduardo Martinez, Camilo Sisnieguez, Betty C. Leiva Sisnieguez, Carlos E. Leiva Carbajal, Horacio A. |
author_sort | Gagliardino, Juan J. |
collection | PubMed |
description | Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs. |
format | Online Article Text |
id | pubmed-8348675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83486752021-08-08 Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis Gagliardino, Juan J. Salazar, Martin R. Espeche, Walter G. Chapasian, Paula E. Tolosa Gomez Garizoain, Daniela Olano, Ricardo D. Stavile, Rodolfo N. Balbín, Eduardo Martinez, Camilo Sisnieguez, Betty C. Leiva Sisnieguez, Carlos E. Leiva Carbajal, Horacio A. J Clin Med Article Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs. MDPI 2021-07-23 /pmc/articles/PMC8348675/ /pubmed/34362033 http://dx.doi.org/10.3390/jcm10153251 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gagliardino, Juan J. Salazar, Martin R. Espeche, Walter G. Chapasian, Paula E. Tolosa Gomez Garizoain, Daniela Olano, Ricardo D. Stavile, Rodolfo N. Balbín, Eduardo Martinez, Camilo Sisnieguez, Betty C. Leiva Sisnieguez, Carlos E. Leiva Carbajal, Horacio A. Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
title | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
title_full | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
title_fullStr | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
title_full_unstemmed | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
title_short | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis |
title_sort | arterial stiffness: its relation with prediabetes and metabolic syndrome and possible pathogenesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348675/ https://www.ncbi.nlm.nih.gov/pubmed/34362033 http://dx.doi.org/10.3390/jcm10153251 |
work_keys_str_mv | AT gagliardinojuanj arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT salazarmartinr arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT espechewalterg arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT chapasianpaulaetolosa arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT gomezgarizoaindaniela arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT olanoricardod arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT stavilerodolfon arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT balbineduardo arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT martinezcamilo arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT sisnieguezbettycleiva arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT sisnieguezcarloseleiva arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis AT carbajalhoracioa arterialstiffnessitsrelationwithprediabetesandmetabolicsyndromeandpossiblepathogenesis |