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Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis

Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal gluco...

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Autores principales: Gagliardino, Juan J., Salazar, Martin R., Espeche, Walter G., Chapasian, Paula E. Tolosa, Gomez Garizoain, Daniela, Olano, Ricardo D., Stavile, Rodolfo N., Balbín, Eduardo, Martinez, Camilo, Sisnieguez, Betty C. Leiva, Sisnieguez, Carlos E. Leiva, Carbajal, Horacio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348675/
https://www.ncbi.nlm.nih.gov/pubmed/34362033
http://dx.doi.org/10.3390/jcm10153251
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author Gagliardino, Juan J.
Salazar, Martin R.
Espeche, Walter G.
Chapasian, Paula E. Tolosa
Gomez Garizoain, Daniela
Olano, Ricardo D.
Stavile, Rodolfo N.
Balbín, Eduardo
Martinez, Camilo
Sisnieguez, Betty C. Leiva
Sisnieguez, Carlos E. Leiva
Carbajal, Horacio A.
author_facet Gagliardino, Juan J.
Salazar, Martin R.
Espeche, Walter G.
Chapasian, Paula E. Tolosa
Gomez Garizoain, Daniela
Olano, Ricardo D.
Stavile, Rodolfo N.
Balbín, Eduardo
Martinez, Camilo
Sisnieguez, Betty C. Leiva
Sisnieguez, Carlos E. Leiva
Carbajal, Horacio A.
author_sort Gagliardino, Juan J.
collection PubMed
description Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs.
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spelling pubmed-83486752021-08-08 Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis Gagliardino, Juan J. Salazar, Martin R. Espeche, Walter G. Chapasian, Paula E. Tolosa Gomez Garizoain, Daniela Olano, Ricardo D. Stavile, Rodolfo N. Balbín, Eduardo Martinez, Camilo Sisnieguez, Betty C. Leiva Sisnieguez, Carlos E. Leiva Carbajal, Horacio A. J Clin Med Article Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs. MDPI 2021-07-23 /pmc/articles/PMC8348675/ /pubmed/34362033 http://dx.doi.org/10.3390/jcm10153251 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gagliardino, Juan J.
Salazar, Martin R.
Espeche, Walter G.
Chapasian, Paula E. Tolosa
Gomez Garizoain, Daniela
Olano, Ricardo D.
Stavile, Rodolfo N.
Balbín, Eduardo
Martinez, Camilo
Sisnieguez, Betty C. Leiva
Sisnieguez, Carlos E. Leiva
Carbajal, Horacio A.
Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
title Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
title_full Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
title_fullStr Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
title_full_unstemmed Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
title_short Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis
title_sort arterial stiffness: its relation with prediabetes and metabolic syndrome and possible pathogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348675/
https://www.ncbi.nlm.nih.gov/pubmed/34362033
http://dx.doi.org/10.3390/jcm10153251
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