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A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348710/ https://www.ncbi.nlm.nih.gov/pubmed/34361723 http://dx.doi.org/10.3390/molecules26154564 |
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author | Cela-López, José M. Camacho Roldán, Claudio J. Gómez-Lizarraga, Gorka Martínez, Vicente |
author_facet | Cela-López, José M. Camacho Roldán, Claudio J. Gómez-Lizarraga, Gorka Martínez, Vicente |
author_sort | Cela-López, José M. |
collection | PubMed |
description | Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity and mortality. For this reason, it is necessary to develop new compounds for their treatment. In this work, our objective is to review the characteristics of the compounds of a new formulation called Itxasol© that is prescribed as an adjuvant for the treatment of UTIs and composed of β-arbutin, umbelliferon and n-acetyl cysteine. This formulation, based on biomimetic principles, makes Itxasol© a broad-spectrum antibiotic with bactericidal, bacteriostatic and antifungal properties that is capable of destroying the biofilm and stopping its formation. It also acts as an anti-inflammatory agent, without the adverse effects associated with the recurrent use of antibiotics that leads to renal nephrotoxicity and other side effects. All these characteristics make Itxasol© an ideal candidate for the treatment of UTIs since it behaves like an antibiotic and with better characteristics than other adjuvants, such as D-mannose and cranberry extracts. |
format | Online Article Text |
id | pubmed-8348710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83487102021-08-08 A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation Cela-López, José M. Camacho Roldán, Claudio J. Gómez-Lizarraga, Gorka Martínez, Vicente Molecules Review Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity and mortality. For this reason, it is necessary to develop new compounds for their treatment. In this work, our objective is to review the characteristics of the compounds of a new formulation called Itxasol© that is prescribed as an adjuvant for the treatment of UTIs and composed of β-arbutin, umbelliferon and n-acetyl cysteine. This formulation, based on biomimetic principles, makes Itxasol© a broad-spectrum antibiotic with bactericidal, bacteriostatic and antifungal properties that is capable of destroying the biofilm and stopping its formation. It also acts as an anti-inflammatory agent, without the adverse effects associated with the recurrent use of antibiotics that leads to renal nephrotoxicity and other side effects. All these characteristics make Itxasol© an ideal candidate for the treatment of UTIs since it behaves like an antibiotic and with better characteristics than other adjuvants, such as D-mannose and cranberry extracts. MDPI 2021-07-28 /pmc/articles/PMC8348710/ /pubmed/34361723 http://dx.doi.org/10.3390/molecules26154564 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cela-López, José M. Camacho Roldán, Claudio J. Gómez-Lizarraga, Gorka Martínez, Vicente A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation |
title | A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation |
title_full | A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation |
title_fullStr | A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation |
title_full_unstemmed | A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation |
title_short | A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation |
title_sort | natural alternative treatment for urinary tract infections: itxasol©, the importance of the formulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348710/ https://www.ncbi.nlm.nih.gov/pubmed/34361723 http://dx.doi.org/10.3390/molecules26154564 |
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