Cargando…

A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity...

Descripción completa

Detalles Bibliográficos
Autores principales: Cela-López, José M., Camacho Roldán, Claudio J., Gómez-Lizarraga, Gorka, Martínez, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348710/
https://www.ncbi.nlm.nih.gov/pubmed/34361723
http://dx.doi.org/10.3390/molecules26154564
_version_ 1783735406317010944
author Cela-López, José M.
Camacho Roldán, Claudio J.
Gómez-Lizarraga, Gorka
Martínez, Vicente
author_facet Cela-López, José M.
Camacho Roldán, Claudio J.
Gómez-Lizarraga, Gorka
Martínez, Vicente
author_sort Cela-López, José M.
collection PubMed
description Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity and mortality. For this reason, it is necessary to develop new compounds for their treatment. In this work, our objective is to review the characteristics of the compounds of a new formulation called Itxasol© that is prescribed as an adjuvant for the treatment of UTIs and composed of β-arbutin, umbelliferon and n-acetyl cysteine. This formulation, based on biomimetic principles, makes Itxasol© a broad-spectrum antibiotic with bactericidal, bacteriostatic and antifungal properties that is capable of destroying the biofilm and stopping its formation. It also acts as an anti-inflammatory agent, without the adverse effects associated with the recurrent use of antibiotics that leads to renal nephrotoxicity and other side effects. All these characteristics make Itxasol© an ideal candidate for the treatment of UTIs since it behaves like an antibiotic and with better characteristics than other adjuvants, such as D-mannose and cranberry extracts.
format Online
Article
Text
id pubmed-8348710
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83487102021-08-08 A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation Cela-López, José M. Camacho Roldán, Claudio J. Gómez-Lizarraga, Gorka Martínez, Vicente Molecules Review Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity and mortality. For this reason, it is necessary to develop new compounds for their treatment. In this work, our objective is to review the characteristics of the compounds of a new formulation called Itxasol© that is prescribed as an adjuvant for the treatment of UTIs and composed of β-arbutin, umbelliferon and n-acetyl cysteine. This formulation, based on biomimetic principles, makes Itxasol© a broad-spectrum antibiotic with bactericidal, bacteriostatic and antifungal properties that is capable of destroying the biofilm and stopping its formation. It also acts as an anti-inflammatory agent, without the adverse effects associated with the recurrent use of antibiotics that leads to renal nephrotoxicity and other side effects. All these characteristics make Itxasol© an ideal candidate for the treatment of UTIs since it behaves like an antibiotic and with better characteristics than other adjuvants, such as D-mannose and cranberry extracts. MDPI 2021-07-28 /pmc/articles/PMC8348710/ /pubmed/34361723 http://dx.doi.org/10.3390/molecules26154564 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cela-López, José M.
Camacho Roldán, Claudio J.
Gómez-Lizarraga, Gorka
Martínez, Vicente
A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
title A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
title_full A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
title_fullStr A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
title_full_unstemmed A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
title_short A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
title_sort natural alternative treatment for urinary tract infections: itxasol©, the importance of the formulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348710/
https://www.ncbi.nlm.nih.gov/pubmed/34361723
http://dx.doi.org/10.3390/molecules26154564
work_keys_str_mv AT celalopezjosem anaturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT camachoroldanclaudioj anaturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT gomezlizarragagorka anaturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT martinezvicente anaturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT celalopezjosem naturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT camachoroldanclaudioj naturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT gomezlizarragagorka naturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation
AT martinezvicente naturalalternativetreatmentforurinarytractinfectionsitxasoltheimportanceoftheformulation