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Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes

Previous studies on changes in body composition of pancreatic cancer patients have only focused on short-term survivors. We studied longitudinal body composition changes and factors affecting them in long-term survivors by analyzing many abdominal computed tomography images using artificial intellig...

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Autores principales: Kong, Hyun-Ho, Kim, Kyung-Won, Ko, You-Sun, Kim, Song-Cheol, Lee, Jae-Hoon, Song, Ki-Byung, Hwang, Dae-Wook, Kim, Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348760/
https://www.ncbi.nlm.nih.gov/pubmed/34362219
http://dx.doi.org/10.3390/jcm10153436
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author Kong, Hyun-Ho
Kim, Kyung-Won
Ko, You-Sun
Kim, Song-Cheol
Lee, Jae-Hoon
Song, Ki-Byung
Hwang, Dae-Wook
Kim, Won
author_facet Kong, Hyun-Ho
Kim, Kyung-Won
Ko, You-Sun
Kim, Song-Cheol
Lee, Jae-Hoon
Song, Ki-Byung
Hwang, Dae-Wook
Kim, Won
author_sort Kong, Hyun-Ho
collection PubMed
description Previous studies on changes in body composition of pancreatic cancer patients have only focused on short-term survivors. We studied longitudinal body composition changes and factors affecting them in long-term survivors by analyzing many abdominal computed tomography images using artificial intelligence technology. Of 302 patients who survived for >36 months after surgery were analyzed. Multivariate logistic regression analysis for factors affecting body composition changes and repeated-measures analysis of variance to observe differences in the course of change according to each factor were performed. In logistic analysis, preoperative sarcopenia and recurrence were the main factors influencing body composition changes at 1 and 3 years after surgery, respectively. In changes of longitudinal body composition, the decrease in body composition was the greatest at 3–6 months postoperatively, and the preoperative status did not recover even 3 years after surgery. Especially, males showed a greater reduction in skeletal muscle (SKM) after surgery than females (p < 0.01). In addition, SKM (p < 0.001) and subcutaneous adipose tissue (p < 0.05) mass rapidly decreased in case of recurrence. In conclusion, long-term survivors of pancreatic cancer did not recover their preoperative body composition status, and preoperative sarcopenia and recurrence influenced body composition changes.
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spelling pubmed-83487602021-08-08 Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes Kong, Hyun-Ho Kim, Kyung-Won Ko, You-Sun Kim, Song-Cheol Lee, Jae-Hoon Song, Ki-Byung Hwang, Dae-Wook Kim, Won J Clin Med Article Previous studies on changes in body composition of pancreatic cancer patients have only focused on short-term survivors. We studied longitudinal body composition changes and factors affecting them in long-term survivors by analyzing many abdominal computed tomography images using artificial intelligence technology. Of 302 patients who survived for >36 months after surgery were analyzed. Multivariate logistic regression analysis for factors affecting body composition changes and repeated-measures analysis of variance to observe differences in the course of change according to each factor were performed. In logistic analysis, preoperative sarcopenia and recurrence were the main factors influencing body composition changes at 1 and 3 years after surgery, respectively. In changes of longitudinal body composition, the decrease in body composition was the greatest at 3–6 months postoperatively, and the preoperative status did not recover even 3 years after surgery. Especially, males showed a greater reduction in skeletal muscle (SKM) after surgery than females (p < 0.01). In addition, SKM (p < 0.001) and subcutaneous adipose tissue (p < 0.05) mass rapidly decreased in case of recurrence. In conclusion, long-term survivors of pancreatic cancer did not recover their preoperative body composition status, and preoperative sarcopenia and recurrence influenced body composition changes. MDPI 2021-08-02 /pmc/articles/PMC8348760/ /pubmed/34362219 http://dx.doi.org/10.3390/jcm10153436 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kong, Hyun-Ho
Kim, Kyung-Won
Ko, You-Sun
Kim, Song-Cheol
Lee, Jae-Hoon
Song, Ki-Byung
Hwang, Dae-Wook
Kim, Won
Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
title Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
title_full Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
title_fullStr Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
title_full_unstemmed Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
title_short Longitudinal Changes in Body Composition of Long-Term Survivors of Pancreatic Head Cancer and Factors Affecting the Changes
title_sort longitudinal changes in body composition of long-term survivors of pancreatic head cancer and factors affecting the changes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348760/
https://www.ncbi.nlm.nih.gov/pubmed/34362219
http://dx.doi.org/10.3390/jcm10153436
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