Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer

Hypoxia is characterized by an inadequate supply of oxygen to tissues, and hypoxic regions are commonly found in solid tumors. The cellular response to hypoxic conditions is mediated through the activation of hypoxia-inducible factors (HIFs) that control the expression of a large number of target ge...

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Detalles Bibliográficos
Autores principales: Taneja, Sakshi, Vetter, Stefan W., Leclerc, Estelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348933/
https://www.ncbi.nlm.nih.gov/pubmed/34360919
http://dx.doi.org/10.3390/ijms22158153
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author Taneja, Sakshi
Vetter, Stefan W.
Leclerc, Estelle
author_facet Taneja, Sakshi
Vetter, Stefan W.
Leclerc, Estelle
author_sort Taneja, Sakshi
collection PubMed
description Hypoxia is characterized by an inadequate supply of oxygen to tissues, and hypoxic regions are commonly found in solid tumors. The cellular response to hypoxic conditions is mediated through the activation of hypoxia-inducible factors (HIFs) that control the expression of a large number of target genes. Recent studies have shown that the receptor for advanced glycation end products (RAGE) participates in hypoxia-dependent cellular adaptation. We review recent evidence on the role of RAGE signaling in tumor biology under hypoxic conditions.
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spelling pubmed-83489332021-08-08 Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer Taneja, Sakshi Vetter, Stefan W. Leclerc, Estelle Int J Mol Sci Review Hypoxia is characterized by an inadequate supply of oxygen to tissues, and hypoxic regions are commonly found in solid tumors. The cellular response to hypoxic conditions is mediated through the activation of hypoxia-inducible factors (HIFs) that control the expression of a large number of target genes. Recent studies have shown that the receptor for advanced glycation end products (RAGE) participates in hypoxia-dependent cellular adaptation. We review recent evidence on the role of RAGE signaling in tumor biology under hypoxic conditions. MDPI 2021-07-29 /pmc/articles/PMC8348933/ /pubmed/34360919 http://dx.doi.org/10.3390/ijms22158153 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Taneja, Sakshi
Vetter, Stefan W.
Leclerc, Estelle
Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
title Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
title_full Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
title_fullStr Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
title_full_unstemmed Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
title_short Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
title_sort hypoxia and the receptor for advanced glycation end products (rage) signaling in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348933/
https://www.ncbi.nlm.nih.gov/pubmed/34360919
http://dx.doi.org/10.3390/ijms22158153
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