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Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?

Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide in both adult and pediatric populations. Treatment options for immune-mediated diseases, including IBDs, are traditional steroids, immunomodulators, and biologics, none of which are...

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Autores principales: Baradaran Ghavami, Shaghayegh, Asadzadeh Aghdaei, Hamid, Sorrentino, Dario, Shahrokh, Shabnam, Farmani, Maryam, Ashrafian, Fatemeh, Dore, Maria Pina, Keshavarz Azizi Raftar, Shahrbanoo, Mobin Khoramjoo, Seyed, Zali, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348973/
https://www.ncbi.nlm.nih.gov/pubmed/34361038
http://dx.doi.org/10.3390/ijms22158274
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author Baradaran Ghavami, Shaghayegh
Asadzadeh Aghdaei, Hamid
Sorrentino, Dario
Shahrokh, Shabnam
Farmani, Maryam
Ashrafian, Fatemeh
Dore, Maria Pina
Keshavarz Azizi Raftar, Shahrbanoo
Mobin Khoramjoo, Seyed
Zali, Mohammad Reza
author_facet Baradaran Ghavami, Shaghayegh
Asadzadeh Aghdaei, Hamid
Sorrentino, Dario
Shahrokh, Shabnam
Farmani, Maryam
Ashrafian, Fatemeh
Dore, Maria Pina
Keshavarz Azizi Raftar, Shahrbanoo
Mobin Khoramjoo, Seyed
Zali, Mohammad Reza
author_sort Baradaran Ghavami, Shaghayegh
collection PubMed
description Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide in both adult and pediatric populations. Treatment options for immune-mediated diseases, including IBDs, are traditional steroids, immunomodulators, and biologics, none of which are capable of inducing long-lasting remission in all patients. Dendritic cells (DCs) play a fundamental role in inducing tolerance and regulating T cells and their tolerogenic functions. Hence, modulation of intestinal mucosal immunity by DCs could provide a novel, additional tool for the treatment of IBD. Recent evidence indicates that probiotic bacteria might impact immunomodulation both in vitro and in vivo by regulating DCs’ maturation and producing tolerogenic DCs (tolDCs) which, in turn, might dampen inflammation. In this review, we will discuss this evidence and the mechanisms of action of probiotics and their metabolites in inducing tolDCs in IBDs and some conditions associated with them.
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spelling pubmed-83489732021-08-08 Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease? Baradaran Ghavami, Shaghayegh Asadzadeh Aghdaei, Hamid Sorrentino, Dario Shahrokh, Shabnam Farmani, Maryam Ashrafian, Fatemeh Dore, Maria Pina Keshavarz Azizi Raftar, Shahrbanoo Mobin Khoramjoo, Seyed Zali, Mohammad Reza Int J Mol Sci Review Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide in both adult and pediatric populations. Treatment options for immune-mediated diseases, including IBDs, are traditional steroids, immunomodulators, and biologics, none of which are capable of inducing long-lasting remission in all patients. Dendritic cells (DCs) play a fundamental role in inducing tolerance and regulating T cells and their tolerogenic functions. Hence, modulation of intestinal mucosal immunity by DCs could provide a novel, additional tool for the treatment of IBD. Recent evidence indicates that probiotic bacteria might impact immunomodulation both in vitro and in vivo by regulating DCs’ maturation and producing tolerogenic DCs (tolDCs) which, in turn, might dampen inflammation. In this review, we will discuss this evidence and the mechanisms of action of probiotics and their metabolites in inducing tolDCs in IBDs and some conditions associated with them. MDPI 2021-07-31 /pmc/articles/PMC8348973/ /pubmed/34361038 http://dx.doi.org/10.3390/ijms22158274 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baradaran Ghavami, Shaghayegh
Asadzadeh Aghdaei, Hamid
Sorrentino, Dario
Shahrokh, Shabnam
Farmani, Maryam
Ashrafian, Fatemeh
Dore, Maria Pina
Keshavarz Azizi Raftar, Shahrbanoo
Mobin Khoramjoo, Seyed
Zali, Mohammad Reza
Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
title Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
title_full Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
title_fullStr Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
title_full_unstemmed Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
title_short Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?
title_sort probiotic-induced tolerogenic dendritic cells: a novel therapy for inflammatory bowel disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348973/
https://www.ncbi.nlm.nih.gov/pubmed/34361038
http://dx.doi.org/10.3390/ijms22158274
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