Role of Rho-Associated Protein Kinase Inhibition As Therapeutic Strategy for Parkinson’s Disease: Dopaminergic Survival and Enhanced Mitophagy

The GTP-binding protein, Rho, plays a significant role in the cellular pathology of Parkinson’s disease. The downstream effector of Rho, Rho-associated kinase (ROCK), performs several functions, including microglial inflammatory response and enhanced Parkin-mediated mitophagy. Its inhibition shows n...

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Detalles Bibliográficos
Autores principales: Quadir, Huma, Hakobyan, Knkush, Gaddam, Mrunanjali, Ojinnaka, Ugochi, Ahmed, Zubayer, Kannan, Amudhan, Mostafa, Jihan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349301/
https://www.ncbi.nlm.nih.gov/pubmed/34377615
http://dx.doi.org/10.7759/cureus.16973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349301/
https://www.ncbi.nlm.nih.gov/pubmed/34377615
http://dx.doi.org/10.7759/cureus.16973

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