Cargando…

A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression

Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50–60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous...

Descripción completa

Detalles Bibliográficos
Autores principales: Mason, David, Capp, Simone J., Stewart, Gavin R., Kempton, Matthew J., Glaser, Karen, Howlin, Patricia, Happé, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349337/
https://www.ncbi.nlm.nih.gov/pubmed/33200352
http://dx.doi.org/10.1007/s10803-020-04763-2
_version_ 1783735547869528064
author Mason, David
Capp, Simone J.
Stewart, Gavin R.
Kempton, Matthew J.
Glaser, Karen
Howlin, Patricia
Happé, Francesca
author_facet Mason, David
Capp, Simone J.
Stewart, Gavin R.
Kempton, Matthew J.
Glaser, Karen
Howlin, Patricia
Happé, Francesca
author_sort Mason, David
collection PubMed
description Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50–60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10803-020-04763-2) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-8349337
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-83493372021-08-20 A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression Mason, David Capp, Simone J. Stewart, Gavin R. Kempton, Matthew J. Glaser, Karen Howlin, Patricia Happé, Francesca J Autism Dev Disord Original Paper Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50–60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10803-020-04763-2) contains supplementary material, which is available to authorized users. Springer US 2020-11-17 2021 /pmc/articles/PMC8349337/ /pubmed/33200352 http://dx.doi.org/10.1007/s10803-020-04763-2 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Mason, David
Capp, Simone J.
Stewart, Gavin R.
Kempton, Matthew J.
Glaser, Karen
Howlin, Patricia
Happé, Francesca
A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
title A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
title_full A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
title_fullStr A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
title_full_unstemmed A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
title_short A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
title_sort meta-analysis of outcome studies of autistic adults: quantifying effect size, quality, and meta-regression
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349337/
https://www.ncbi.nlm.nih.gov/pubmed/33200352
http://dx.doi.org/10.1007/s10803-020-04763-2
work_keys_str_mv AT masondavid ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT cappsimonej ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT stewartgavinr ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT kemptonmatthewj ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT glaserkaren ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT howlinpatricia ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT happefrancesca ametaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT masondavid metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT cappsimonej metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT stewartgavinr metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT kemptonmatthewj metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT glaserkaren metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT howlinpatricia metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression
AT happefrancesca metaanalysisofoutcomestudiesofautisticadultsquantifyingeffectsizequalityandmetaregression