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Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients

OBJECTIVES: There is conflicting evidence about the efficacy of statin use in regard to clinical outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis was performed to examine the effect of statin use on mortality in COVID-19 patients. METHODS: The elec...

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Autores principales: Diaz-Arocutipa, Carlos, Melgar-Talavera, Beatriz, Alvarado-Yarasca, Ángel, Saravia-Bartra, María M., Cazorla, Pedro, Belzusarri, Iván, Hernandez, Adrian V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349445/
https://www.ncbi.nlm.nih.gov/pubmed/34375760
http://dx.doi.org/10.1016/j.ijid.2021.08.004
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author Diaz-Arocutipa, Carlos
Melgar-Talavera, Beatriz
Alvarado-Yarasca, Ángel
Saravia-Bartra, María M.
Cazorla, Pedro
Belzusarri, Iván
Hernandez, Adrian V.
author_facet Diaz-Arocutipa, Carlos
Melgar-Talavera, Beatriz
Alvarado-Yarasca, Ángel
Saravia-Bartra, María M.
Cazorla, Pedro
Belzusarri, Iván
Hernandez, Adrian V.
author_sort Diaz-Arocutipa, Carlos
collection PubMed
description OBJECTIVES: There is conflicting evidence about the efficacy of statin use in regard to clinical outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis was performed to examine the effect of statin use on mortality in COVID-19 patients. METHODS: The electronic databases were searched, from inception to March 3, 2021. Unadjusted and adjusted effect estimates with their 95% confidence intervals (95% CI) were pooled using random-effects models. RESULTS: Twenty-five cohort studies involving 147 824 patients were included. The mean age of the patients ranged from 44.9 to 70.9 years; 57% of patients were male and 43% were female. The use of statins was not associated with mortality when applying the unadjusted risk ratio (uRR 1.16, 95% CI 0.86–1.57; 19 studies). In contrast, meta-analyses of the adjusted odds ratio (aOR 0.67, 95% CI 0.52–0.86; 11 studies) and adjusted hazard ratio (aHR 0.73, 95% CI 0.58–0.91; 10 studies) showed that statins were independently associated with a significant reduction in mortality. Subgroup analyses showed that only chronic use of statins significantly reduced mortality according to the adjusted models. CONCLUSIONS: The use of statins was found to be associated with a lower risk of mortality in COVID-19 patients based on adjusted effects of cohort studies. However, randomized controlled trials are still needed to confirm these findings.
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spelling pubmed-83494452021-08-09 Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients Diaz-Arocutipa, Carlos Melgar-Talavera, Beatriz Alvarado-Yarasca, Ángel Saravia-Bartra, María M. Cazorla, Pedro Belzusarri, Iván Hernandez, Adrian V. Int J Infect Dis Article OBJECTIVES: There is conflicting evidence about the efficacy of statin use in regard to clinical outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis was performed to examine the effect of statin use on mortality in COVID-19 patients. METHODS: The electronic databases were searched, from inception to March 3, 2021. Unadjusted and adjusted effect estimates with their 95% confidence intervals (95% CI) were pooled using random-effects models. RESULTS: Twenty-five cohort studies involving 147 824 patients were included. The mean age of the patients ranged from 44.9 to 70.9 years; 57% of patients were male and 43% were female. The use of statins was not associated with mortality when applying the unadjusted risk ratio (uRR 1.16, 95% CI 0.86–1.57; 19 studies). In contrast, meta-analyses of the adjusted odds ratio (aOR 0.67, 95% CI 0.52–0.86; 11 studies) and adjusted hazard ratio (aHR 0.73, 95% CI 0.58–0.91; 10 studies) showed that statins were independently associated with a significant reduction in mortality. Subgroup analyses showed that only chronic use of statins significantly reduced mortality according to the adjusted models. CONCLUSIONS: The use of statins was found to be associated with a lower risk of mortality in COVID-19 patients based on adjusted effects of cohort studies. However, randomized controlled trials are still needed to confirm these findings. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-09 2021-08-08 /pmc/articles/PMC8349445/ /pubmed/34375760 http://dx.doi.org/10.1016/j.ijid.2021.08.004 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Diaz-Arocutipa, Carlos
Melgar-Talavera, Beatriz
Alvarado-Yarasca, Ángel
Saravia-Bartra, María M.
Cazorla, Pedro
Belzusarri, Iván
Hernandez, Adrian V.
Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
title Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
title_full Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
title_fullStr Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
title_full_unstemmed Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
title_short Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
title_sort statins reduce mortality in patients with covid-19: an updated meta-analysis of 147 824 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349445/
https://www.ncbi.nlm.nih.gov/pubmed/34375760
http://dx.doi.org/10.1016/j.ijid.2021.08.004
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