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Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation

Influenza viruses, respiratory syncytial virus (RSV), and SARS-COV2 are among the most dangerous respiratory viruses. Zinc is one of the essential micronutrients and is very important in the immune system. The aim of this narrative review is to review the most interesting findings about the importan...

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Autores principales: Sadeghsoltani, Fatemeh, Mohammadzadeh, Iraj, Safari, Mir-Meghdad, Hassanpour, Parisa, Izadpanah, Melika, Qujeq, Durdi, Moein, Soheila, Vaghari-Tabari, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349606/
https://www.ncbi.nlm.nih.gov/pubmed/34368933
http://dx.doi.org/10.1007/s12011-021-02859-z
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author Sadeghsoltani, Fatemeh
Mohammadzadeh, Iraj
Safari, Mir-Meghdad
Hassanpour, Parisa
Izadpanah, Melika
Qujeq, Durdi
Moein, Soheila
Vaghari-Tabari, Mostafa
author_facet Sadeghsoltani, Fatemeh
Mohammadzadeh, Iraj
Safari, Mir-Meghdad
Hassanpour, Parisa
Izadpanah, Melika
Qujeq, Durdi
Moein, Soheila
Vaghari-Tabari, Mostafa
author_sort Sadeghsoltani, Fatemeh
collection PubMed
description Influenza viruses, respiratory syncytial virus (RSV), and SARS-COV2 are among the most dangerous respiratory viruses. Zinc is one of the essential micronutrients and is very important in the immune system. The aim of this narrative review is to review the most interesting findings about the importance of zinc in the anti-viral immune response in the respiratory tract and defense against influenza, RSV, and SARS-COV2 infections. The most interesting findings on the role of zinc in regulating immunity in the respiratory tract and the relationship between zinc and acute respiratory distress syndrome (ARDS) are reviewed, as well. Besides, current findings regarding the relationship between zinc and the effectiveness of respiratory viruses’ vaccines are reviewed. The results of reviewed studies have shown that zinc and some zinc-dependent proteins are involved in anti-viral defense and immune regulation in the respiratory tract. It seems that zinc can reduce the viral titer following influenza infection. Zinc may reduce RSV burden in the lungs. Zinc can be effective in reducing the duration of viral pneumonia symptoms. Zinc may enhance the effectiveness of hydroxychloroquine in reducing mortality rate in COVID-19 patients. Besides, zinc has a positive effect in preventing ARDS and ventilator-induced lung damage. The relationship between zinc levels and the effectiveness of respiratory viruses’ vaccines, especially influenza vaccines, is still unclear, and the findings are somewhat contradictory. In conclusion, zinc has anti-viral properties and is important in defending against respiratory viral infections and regulating the immune response in the respiratory tract.
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spelling pubmed-83496062021-08-09 Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation Sadeghsoltani, Fatemeh Mohammadzadeh, Iraj Safari, Mir-Meghdad Hassanpour, Parisa Izadpanah, Melika Qujeq, Durdi Moein, Soheila Vaghari-Tabari, Mostafa Biol Trace Elem Res Article Influenza viruses, respiratory syncytial virus (RSV), and SARS-COV2 are among the most dangerous respiratory viruses. Zinc is one of the essential micronutrients and is very important in the immune system. The aim of this narrative review is to review the most interesting findings about the importance of zinc in the anti-viral immune response in the respiratory tract and defense against influenza, RSV, and SARS-COV2 infections. The most interesting findings on the role of zinc in regulating immunity in the respiratory tract and the relationship between zinc and acute respiratory distress syndrome (ARDS) are reviewed, as well. Besides, current findings regarding the relationship between zinc and the effectiveness of respiratory viruses’ vaccines are reviewed. The results of reviewed studies have shown that zinc and some zinc-dependent proteins are involved in anti-viral defense and immune regulation in the respiratory tract. It seems that zinc can reduce the viral titer following influenza infection. Zinc may reduce RSV burden in the lungs. Zinc can be effective in reducing the duration of viral pneumonia symptoms. Zinc may enhance the effectiveness of hydroxychloroquine in reducing mortality rate in COVID-19 patients. Besides, zinc has a positive effect in preventing ARDS and ventilator-induced lung damage. The relationship between zinc levels and the effectiveness of respiratory viruses’ vaccines, especially influenza vaccines, is still unclear, and the findings are somewhat contradictory. In conclusion, zinc has anti-viral properties and is important in defending against respiratory viral infections and regulating the immune response in the respiratory tract. Springer US 2021-08-09 2022 /pmc/articles/PMC8349606/ /pubmed/34368933 http://dx.doi.org/10.1007/s12011-021-02859-z Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Sadeghsoltani, Fatemeh
Mohammadzadeh, Iraj
Safari, Mir-Meghdad
Hassanpour, Parisa
Izadpanah, Melika
Qujeq, Durdi
Moein, Soheila
Vaghari-Tabari, Mostafa
Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
title Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
title_full Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
title_fullStr Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
title_full_unstemmed Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
title_short Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation
title_sort zinc and respiratory viral infections: important trace element in anti-viral response and immune regulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349606/
https://www.ncbi.nlm.nih.gov/pubmed/34368933
http://dx.doi.org/10.1007/s12011-021-02859-z
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