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T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury

T cells participate in the repair process and immune response in the CNS post‐traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post‐traumatic injury. The repair of traumatic CNS injury is a long‐te...

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Detalles Bibliográficos
Autores principales: Xu, Lvwan, Ye, Xin, Wang, Qingyi, Xu, Bihan, Zhong, Jinjie, Chen, Ying‐ying, Wang, Lin‐lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349661/
https://www.ncbi.nlm.nih.gov/pubmed/34189783
http://dx.doi.org/10.1111/cpr.13092
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author Xu, Lvwan
Ye, Xin
Wang, Qingyi
Xu, Bihan
Zhong, Jinjie
Chen, Ying‐ying
Wang, Lin‐lin
author_facet Xu, Lvwan
Ye, Xin
Wang, Qingyi
Xu, Bihan
Zhong, Jinjie
Chen, Ying‐ying
Wang, Lin‐lin
author_sort Xu, Lvwan
collection PubMed
description T cells participate in the repair process and immune response in the CNS post‐traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post‐traumatic injury. The repair of traumatic CNS injury is a long‐term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry‐based flow cytometry, modern live‐cell imaging, etc, research focusing on T cells is becoming one of the valuable directions for the future therapy of traumatic CNS injury. In this review, we summarized the infiltration, contribution and regulation of T cells in post‐traumatic injury, discussed the clinical significance and predicted the future research direction.
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spelling pubmed-83496612021-08-15 T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury Xu, Lvwan Ye, Xin Wang, Qingyi Xu, Bihan Zhong, Jinjie Chen, Ying‐ying Wang, Lin‐lin Cell Prolif Reviews T cells participate in the repair process and immune response in the CNS post‐traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post‐traumatic injury. The repair of traumatic CNS injury is a long‐term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry‐based flow cytometry, modern live‐cell imaging, etc, research focusing on T cells is becoming one of the valuable directions for the future therapy of traumatic CNS injury. In this review, we summarized the infiltration, contribution and regulation of T cells in post‐traumatic injury, discussed the clinical significance and predicted the future research direction. John Wiley and Sons Inc. 2021-06-29 /pmc/articles/PMC8349661/ /pubmed/34189783 http://dx.doi.org/10.1111/cpr.13092 Text en © 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xu, Lvwan
Ye, Xin
Wang, Qingyi
Xu, Bihan
Zhong, Jinjie
Chen, Ying‐ying
Wang, Lin‐lin
T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
title T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
title_full T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
title_fullStr T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
title_full_unstemmed T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
title_short T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
title_sort t‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349661/
https://www.ncbi.nlm.nih.gov/pubmed/34189783
http://dx.doi.org/10.1111/cpr.13092
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