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T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury
T cells participate in the repair process and immune response in the CNS post‐traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post‐traumatic injury. The repair of traumatic CNS injury is a long‐te...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349661/ https://www.ncbi.nlm.nih.gov/pubmed/34189783 http://dx.doi.org/10.1111/cpr.13092 |
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author | Xu, Lvwan Ye, Xin Wang, Qingyi Xu, Bihan Zhong, Jinjie Chen, Ying‐ying Wang, Lin‐lin |
author_facet | Xu, Lvwan Ye, Xin Wang, Qingyi Xu, Bihan Zhong, Jinjie Chen, Ying‐ying Wang, Lin‐lin |
author_sort | Xu, Lvwan |
collection | PubMed |
description | T cells participate in the repair process and immune response in the CNS post‐traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post‐traumatic injury. The repair of traumatic CNS injury is a long‐term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry‐based flow cytometry, modern live‐cell imaging, etc, research focusing on T cells is becoming one of the valuable directions for the future therapy of traumatic CNS injury. In this review, we summarized the infiltration, contribution and regulation of T cells in post‐traumatic injury, discussed the clinical significance and predicted the future research direction. |
format | Online Article Text |
id | pubmed-8349661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83496612021-08-15 T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury Xu, Lvwan Ye, Xin Wang, Qingyi Xu, Bihan Zhong, Jinjie Chen, Ying‐ying Wang, Lin‐lin Cell Prolif Reviews T cells participate in the repair process and immune response in the CNS post‐traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post‐traumatic injury. The repair of traumatic CNS injury is a long‐term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry‐based flow cytometry, modern live‐cell imaging, etc, research focusing on T cells is becoming one of the valuable directions for the future therapy of traumatic CNS injury. In this review, we summarized the infiltration, contribution and regulation of T cells in post‐traumatic injury, discussed the clinical significance and predicted the future research direction. John Wiley and Sons Inc. 2021-06-29 /pmc/articles/PMC8349661/ /pubmed/34189783 http://dx.doi.org/10.1111/cpr.13092 Text en © 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Xu, Lvwan Ye, Xin Wang, Qingyi Xu, Bihan Zhong, Jinjie Chen, Ying‐ying Wang, Lin‐lin T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
title | T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
title_full | T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
title_fullStr | T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
title_full_unstemmed | T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
title_short | T‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
title_sort | t‐cell infiltration, contribution and regulation in the central nervous system post‐traumatic injury |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349661/ https://www.ncbi.nlm.nih.gov/pubmed/34189783 http://dx.doi.org/10.1111/cpr.13092 |
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