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Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic

BACKGROUND: Mast cell-related symptoms might be influenced by mental health status in mastocytosis. In this study, we aimed to investigate the influence of mental health problems developed during the COVID-19 pandemic on the course of mastocytosis. METHODS: Mental health status in 60 adult patients...

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Autores principales: Öztop, Nida, Demir, Semra, Beyaz, Şengül, Ünal, Derya, Çolakoğlu, Bahauddin, Büyüköztürk, Suna, Gelincik, Aslı
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Allergology. Production and hosting by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349680/
https://www.ncbi.nlm.nih.gov/pubmed/34483018
http://dx.doi.org/10.1016/j.alit.2021.08.002
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author Öztop, Nida
Demir, Semra
Beyaz, Şengül
Ünal, Derya
Çolakoğlu, Bahauddin
Büyüköztürk, Suna
Gelincik, Aslı
author_facet Öztop, Nida
Demir, Semra
Beyaz, Şengül
Ünal, Derya
Çolakoğlu, Bahauddin
Büyüköztürk, Suna
Gelincik, Aslı
author_sort Öztop, Nida
collection PubMed
description BACKGROUND: Mast cell-related symptoms might be influenced by mental health status in mastocytosis. In this study, we aimed to investigate the influence of mental health problems developed during the COVID-19 pandemic on the course of mastocytosis. METHODS: Mental health status in 60 adult patients with mastocytosis was prospectively evaluated with the total Depression-Anxiety-Stress Scale (tDASS-21) and Fear of COVID-19 Scale (FCV–19S) in the lockdown period (LP) and the return to normal period (RTNP) during the pandemic. The disease course was assessed from emergency and outpatient medical reports, including Scoring Mastocytosis (SCORMA) index and serum baseline tryptase levels, by telephone interviews and clinical visits. RESULTS: The mean FCV-19S and median tDASS-21 scores were significantly higher in LP than RTNP (p < 0.001) and there was a positive correlation between FCV-19S and tDASS-21 in LP (r = 0.820, p < 0.001) and in RTNP (r = 0.572 p= <0.001). Disease-related symptoms including skin lesions, flushing and anaphylaxis attacks increased in 22 patients in LP, and in this group, mean FCV-19S and median tDASS-21 were higher than those without symptom exacerbation (p < 0.001). During the study period, four (6.7%) patients who experienced COVID-19 recovered without any requirement for hospitalization and had not experienced symptom exacerbation. CONCLUSIONS: Fear of COVID-19 can be a reason for mental health changes, including depression, anxiety and stress which may further increase mast cell-related symptoms. Therefore, psychological support is important to control the severity of mast cell-related symptoms in mastocytosis during a pandemic.
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spelling pubmed-83496802021-08-09 Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic Öztop, Nida Demir, Semra Beyaz, Şengül Ünal, Derya Çolakoğlu, Bahauddin Büyüköztürk, Suna Gelincik, Aslı Allergol Int Original Article BACKGROUND: Mast cell-related symptoms might be influenced by mental health status in mastocytosis. In this study, we aimed to investigate the influence of mental health problems developed during the COVID-19 pandemic on the course of mastocytosis. METHODS: Mental health status in 60 adult patients with mastocytosis was prospectively evaluated with the total Depression-Anxiety-Stress Scale (tDASS-21) and Fear of COVID-19 Scale (FCV–19S) in the lockdown period (LP) and the return to normal period (RTNP) during the pandemic. The disease course was assessed from emergency and outpatient medical reports, including Scoring Mastocytosis (SCORMA) index and serum baseline tryptase levels, by telephone interviews and clinical visits. RESULTS: The mean FCV-19S and median tDASS-21 scores were significantly higher in LP than RTNP (p < 0.001) and there was a positive correlation between FCV-19S and tDASS-21 in LP (r = 0.820, p < 0.001) and in RTNP (r = 0.572 p= <0.001). Disease-related symptoms including skin lesions, flushing and anaphylaxis attacks increased in 22 patients in LP, and in this group, mean FCV-19S and median tDASS-21 were higher than those without symptom exacerbation (p < 0.001). During the study period, four (6.7%) patients who experienced COVID-19 recovered without any requirement for hospitalization and had not experienced symptom exacerbation. CONCLUSIONS: Fear of COVID-19 can be a reason for mental health changes, including depression, anxiety and stress which may further increase mast cell-related symptoms. Therefore, psychological support is important to control the severity of mast cell-related symptoms in mastocytosis during a pandemic. Japanese Society of Allergology. Production and hosting by Elsevier B.V. 2022-01 2021-08-09 /pmc/articles/PMC8349680/ /pubmed/34483018 http://dx.doi.org/10.1016/j.alit.2021.08.002 Text en © 2021 Japanese Society of Allergology. Production and hosting by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Öztop, Nida
Demir, Semra
Beyaz, Şengül
Ünal, Derya
Çolakoğlu, Bahauddin
Büyüköztürk, Suna
Gelincik, Aslı
Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic
title Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic
title_full Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic
title_fullStr Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic
title_full_unstemmed Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic
title_short Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic
title_sort impact of mental health on disease activity in mastocytosis during covid-19 pandemic
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349680/
https://www.ncbi.nlm.nih.gov/pubmed/34483018
http://dx.doi.org/10.1016/j.alit.2021.08.002
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