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Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves
One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene seq...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349807/ https://www.ncbi.nlm.nih.gov/pubmed/34024871 http://dx.doi.org/10.1292/jvms.21-0166 |
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author | KOMATSU, Tetsuya YOSHIDA, Erina SHIGENAGA, Ayumi YASUIE, Nozomi UCHIYAMA, Shintaro TAKAMURA, Yuji SUGIE, Kennosuke KIMURA, Kumiko HARITANI, Makoto SHIBAHARA, Tomoyuki |
author_facet | KOMATSU, Tetsuya YOSHIDA, Erina SHIGENAGA, Ayumi YASUIE, Nozomi UCHIYAMA, Shintaro TAKAMURA, Yuji SUGIE, Kennosuke KIMURA, Kumiko HARITANI, Makoto SHIBAHARA, Tomoyuki |
author_sort | KOMATSU, Tetsuya |
collection | PubMed |
description | One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene sequencing of the No. 1 isolate and bacterial extracts from formalin fixed paraffin embedded sections of No. 2 revealed that both samples were K. pneumoniae. The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin. Immunosuppression is a significant septicemic K. pneumoniae infection risk factor. Our study provides new aspects regarding K. pneumoniae infections in cattle, bacterial meningoencephalitis differentiation, and K. pneumoniae and bacterial meningoencephalitis treatments. |
format | Online Article Text |
id | pubmed-8349807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83498072021-08-12 Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves KOMATSU, Tetsuya YOSHIDA, Erina SHIGENAGA, Ayumi YASUIE, Nozomi UCHIYAMA, Shintaro TAKAMURA, Yuji SUGIE, Kennosuke KIMURA, Kumiko HARITANI, Makoto SHIBAHARA, Tomoyuki J Vet Med Sci Pathology One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene sequencing of the No. 1 isolate and bacterial extracts from formalin fixed paraffin embedded sections of No. 2 revealed that both samples were K. pneumoniae. The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin. Immunosuppression is a significant septicemic K. pneumoniae infection risk factor. Our study provides new aspects regarding K. pneumoniae infections in cattle, bacterial meningoencephalitis differentiation, and K. pneumoniae and bacterial meningoencephalitis treatments. The Japanese Society of Veterinary Science 2021-05-24 2021-07 /pmc/articles/PMC8349807/ /pubmed/34024871 http://dx.doi.org/10.1292/jvms.21-0166 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Pathology KOMATSU, Tetsuya YOSHIDA, Erina SHIGENAGA, Ayumi YASUIE, Nozomi UCHIYAMA, Shintaro TAKAMURA, Yuji SUGIE, Kennosuke KIMURA, Kumiko HARITANI, Makoto SHIBAHARA, Tomoyuki Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves |
title | Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves |
title_full | Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves |
title_fullStr | Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves |
title_full_unstemmed | Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves |
title_short | Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves |
title_sort | fatal suppurative meningoencephalitis caused by klebsiella pneumoniae in two calves |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349807/ https://www.ncbi.nlm.nih.gov/pubmed/34024871 http://dx.doi.org/10.1292/jvms.21-0166 |
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