Genetic modifiers regulating DNA replication and double strand break repair are associated with differences in mammary tumors in mouse models of Li-Fraumeni Syndrome

Breast cancer is the most common tumor among women with inherited variants in the TP53 tumor suppressor, but onset varies widely suggesting interactions with genetic or environmental factors. Rodent models haploinsufficent for Trp53 also develop a wide variety of malignancies associated with Li-Frau...

Descripción completa

Detalles Bibliográficos
Autores principales: Majhi, Prabin Dhangada, Griner, Nicholas B., Mayfield, Jacob A., Compton, Shannon, Kane, Jeffrey J., Baptiste, Trevor A., Dunphy, Karen A., Roberts, Amy L., Schneider, Sallie S., Savage, Evan M., Patel, Divyen, Blackburn, Anneke C., Maurus, Kim Joana, Wiesmüller, Lisa, Jerry, D. Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349885/
https://www.ncbi.nlm.nih.gov/pubmed/34183771
http://dx.doi.org/10.1038/s41388-021-01892-5

Ejemplares similares

Ejemplares similares