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HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium

BACKGROUND AND AIMS: The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to HER2 mutations, colon cancer patients also possess co-occurring mutations in genes such as APC. Here, we investigated the role of HER2 and APC mutations o...

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Detalles Bibliográficos
Autores principales:	Murray, Elisa, Cheng, Xiaoqing, Krishna, Anagha, Jin, Xiaohua, Ohara, Takahiro E., Stappenbeck, Thaddeus S., Bose, Ron
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350008/ https://www.ncbi.nlm.nih.gov/pubmed/33930605 http://dx.doi.org/10.1016/j.jcmgh.2021.04.012

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