Cargando…

Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1

BACKGROUND: High incidence of metastasis is the main cause of death for small cell lung cancer (SCLC), with its underlying molecular mechanisms remain unclear. Exosomal miRNAs are important regulators in metastatic processes of various tumors, but their specific role in SCLC metastasis is unknown. M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mao, Shuangshuang, Zheng, Sufei, Lu, Zhiliang, Wang, Xinfeng, Wang, Yan, Zhang, Guochao, Xu, Haiyan, Huang, Jianbing, Lei, Yuanyuan, Liu, Chengming, Sun, Nan, He, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350081/ https://www.ncbi.nlm.nih.gov/pubmed/34430355 http://dx.doi.org/10.21037/tlcr-21-356

Ejemplares similares

Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer
por: Mao, Shuangshuang, et al.
Publicado: (2020)

ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expression to promote CA125 secretion and the metastasis of lung cancer cells
por: lei, Yuanyuan, et al.
Publicado: (2020)

S100A7 as a potential diagnostic and prognostic biomarker of esophageal squamous cell carcinoma promotes M2 macrophage infiltration and angiogenesis
por: Lu, Zhiliang, et al.
Publicado: (2021)

Combined detection of aneuploid circulating tumor‐derived endothelial cells and circulating tumor cells may improve diagnosis of early stage non‐small‐cell lung cancer
por: Lei, Yuanyuan, et al.
Publicado: (2020)

The TGFβ-Induced Long Non-coding RNA TBULC Promotes the Invasion and Migration of Non-small Cell Lung Cancer Cells and Indicates Poor Prognosis
por: Zheng, Sufei, et al.
Publicado: (2019)

PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing
por: Mao, Shuangshuang, et al.
Publicado: (2019)

The membrane-bound and soluble form of melanotransferrin function independently in the diagnosis and targeted therapy of lung cancer
por: Lei, Yuanyuan, et al.
Publicado: (2020)

The average copy number variation (CNVA) of chromosome fragments is a potential surrogate for tumor mutational burden in predicting responses to immunotherapy in non‐small‐cell lung cancer
por: Lei, Yuanyuan, et al.
Publicado: (2021)

Tumor microenvironment characterization identifies two lung adenocarcinoma subtypes with specific immune and metabolic state
por: Huang, Jianbing, et al.
Publicado: (2020)

Enhancement of diagnostic performance in lung cancers by combining CEA and CA125 with autoantibodies detection
por: Zang, Ruochuan, et al.
Publicado: (2019)

A novel recurrence-associated metabolic prognostic model for risk stratification and therapeutic response prediction in patients with stage I lung adenocarcinoma
por: Liu, Chengming, et al.
Publicado: (2021)

Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity
por: Zang, Ruochuan, et al.
Publicado: (2019)

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2
por: Wang, Feng, et al.
Publicado: (2021)

The blood–brain and gut–vascular barriers: from the perspective of claudins
por: Scalise, Anna Agata, et al.
Publicado: (2021)

Intestinal Barrier, Claudins and Mycotoxins
por: Kozieł, Marta Justyna, et al.
Publicado: (2021)

Development and external validation of a composite immune-clinical prognostic model associated with EGFR mutation in East-Asian patients with lung adenocarcinoma
por: Liu, Chengming, et al.
Publicado: (2021)

miR-375 suppresses the growth and metastasis of esophageal squamous cell carcinoma by targeting PRDX1
por: Wu, Kunpeng, et al.
Publicado: (2022)

Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer
por: Jin, Runsen, et al.
Publicado: (2020)

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression
por: Hashimoto, Rina, et al.
Publicado: (2022)

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer
por: Li, Jianghong, et al.
Publicado: (2009)

S100A7 attenuates immunotherapy by enhancing immunosuppressive tumor microenvironment in lung squamous cell carcinoma
por: Liu, Chengming, et al.
Publicado: (2022)

KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer
por: Liu, Chengming, et al.
Publicado: (2022)

Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis
por: Harrell, J. Chuck, et al.
Publicado: (2013)

Multiple Myeloma Side Population Cells Promote Dexamethasone Resistance of Main Population Cells through Exosome Metastasis of LncRNA SNHG16
por: Yang, Xi, et al.
Publicado: (2023)

Holey barrier: claudins and the regulation of brain endothelial permeability
por: Matter, Karl, et al.
Publicado: (2003)

Exosomes from LNCaP cells promote osteoblast activity through miR-375 transfer
por: Li, Su-Liang, et al.
Publicado: (2019)

Sequential biphasic changes in claudin1 and claudin4 expression are correlated to colorectal cancer progression and liver metastasis
por: Georges, Rania, et al.
Publicado: (2012)

Exosomal CagA from Helicobacter pylori aggravates intestinal epithelium barrier dysfunction in chronic colitis by facilitating Claudin-2 expression
por: Guo, Yinjie, et al.
Publicado: (2022)

Distinct Origin of Claudin7 in Early Tumor Endosomes Affects Exosome Assembly
por: Kyuno, Daisuke, et al.
Publicado: (2019)

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1–deficient mice
por: Furuse, Mikio, et al.
Publicado: (2002)

Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer
por: Li, Jinyun, et al.
Publicado: (2017)

Breaking Barriers
por: Bento, Ricardo Ferreira
Publicado: (2013)

Afadin cooperates with Claudin-2 to promote breast cancer metastasis
por: Tabariès, Sébastien, et al.
Publicado: (2019)

The claudins
por: Lal-Nag, Madhu, et al.
Publicado: (2009)

Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance
por: Che, Yun, et al.
Publicado: (2018)

A Claudin-9–Based Ion Permeability Barrier Is Essential for Hearing
por: Nakano, Yoko, et al.
Publicado: (2009)

Regulation of claudins in blood-tissue barriers under physiological and pathological states
por: Gonçalves, Andreia, et al.
Publicado: (2013)

Complexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier
por: Kratzer, Ingrid, et al.
Publicado: (2012)

The Role of Barrier Dysfunction and Change of Claudin Expression in Inflammatory Bowel Disease
por: Kim, Tae Il
Publicado: (2015)

Claudin may be a Potential Biomarker for Epithelial Barrier Dysfunction in Asthma
por: Jin, Hyun Jung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_envrgb5unp870oe7du05jrdd5s