Cargando…

Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes

Introduction Hypogonadotropic hypogonadism is a common disorder associated with type 2 diabetes. Hypogonadotropic hypogonadism in type 2 diabetic patients requires further assessment to understand the etiology, and the possible consequences, complications, and treatment This study aims to highlight...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumari, Naina, Khan, Anoosha, Shaikh, Usman, Lobes, Kimberly, Kumar, Deepak, Suman, FNU, Bhutto, Naila S, Anees, Faryal, Shahid, Simra, Rizwan, Amber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350217/
https://www.ncbi.nlm.nih.gov/pubmed/34381648
http://dx.doi.org/10.7759/cureus.16288
_version_ 1783735708559605760
author Kumari, Naina
Khan, Anoosha
Shaikh, Usman
Lobes, Kimberly
Kumar, Deepak
Suman, FNU
Bhutto, Naila S
Anees, Faryal
Shahid, Simra
Rizwan, Amber
author_facet Kumari, Naina
Khan, Anoosha
Shaikh, Usman
Lobes, Kimberly
Kumar, Deepak
Suman, FNU
Bhutto, Naila S
Anees, Faryal
Shahid, Simra
Rizwan, Amber
author_sort Kumari, Naina
collection PubMed
description Introduction Hypogonadotropic hypogonadism is a common disorder associated with type 2 diabetes. Hypogonadotropic hypogonadism in type 2 diabetic patients requires further assessment to understand the etiology, and the possible consequences, complications, and treatment This study aims to highlight the testosterone level in type 2 diabetes mellitus (DM). Moreover, it further emphasizes the association of testosterone with the duration of DM. Materials and method This case-control survey was conducted from September 2020 to March 2021 in the outpatient department of internal medicine in a tertiary care hospital in Pakistan. The experiment group included 200 diabetic male participants aged between 30 and 69 years. In the control group, 200 participants without DM were enrolled in the study. The venous blood sample was collected via phlebotomy and sent to the laboratory to test for total testosterone level. Results The mean total testosterone level was significantly lower in diabetic patients compared to the non-diabetic patients (8.9 ± 5.1 mmol/L vs. 14.1 ± 7.2 mmol/L; p-value: <0.0001) and the prevalence of androgen deficiency was significantly higher in diabetic patients compared to non-diabetic patients (45.5% vs. 20.5%; p-value: <0.00001). For each age group, the mean total testosterone level was significantly higher in the diabetic group compared to the non-diabetic group. There was a significant decline in mean total testosterone level as the duration of diabetes increased (p-value: 0.01). Conclusion Strong interlink between type 2 DM and low testosterone level has once again highlighted the importance of a broader approach toward men presenting in the diabetic clinic and provided a huge ground for prescribing testosterone replacement therapy in hypogonadal men with DM.
format Online
Article
Text
id pubmed-8350217
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-83502172021-08-10 Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes Kumari, Naina Khan, Anoosha Shaikh, Usman Lobes, Kimberly Kumar, Deepak Suman, FNU Bhutto, Naila S Anees, Faryal Shahid, Simra Rizwan, Amber Cureus Endocrinology/Diabetes/Metabolism Introduction Hypogonadotropic hypogonadism is a common disorder associated with type 2 diabetes. Hypogonadotropic hypogonadism in type 2 diabetic patients requires further assessment to understand the etiology, and the possible consequences, complications, and treatment This study aims to highlight the testosterone level in type 2 diabetes mellitus (DM). Moreover, it further emphasizes the association of testosterone with the duration of DM. Materials and method This case-control survey was conducted from September 2020 to March 2021 in the outpatient department of internal medicine in a tertiary care hospital in Pakistan. The experiment group included 200 diabetic male participants aged between 30 and 69 years. In the control group, 200 participants without DM were enrolled in the study. The venous blood sample was collected via phlebotomy and sent to the laboratory to test for total testosterone level. Results The mean total testosterone level was significantly lower in diabetic patients compared to the non-diabetic patients (8.9 ± 5.1 mmol/L vs. 14.1 ± 7.2 mmol/L; p-value: <0.0001) and the prevalence of androgen deficiency was significantly higher in diabetic patients compared to non-diabetic patients (45.5% vs. 20.5%; p-value: <0.00001). For each age group, the mean total testosterone level was significantly higher in the diabetic group compared to the non-diabetic group. There was a significant decline in mean total testosterone level as the duration of diabetes increased (p-value: 0.01). Conclusion Strong interlink between type 2 DM and low testosterone level has once again highlighted the importance of a broader approach toward men presenting in the diabetic clinic and provided a huge ground for prescribing testosterone replacement therapy in hypogonadal men with DM. Cureus 2021-07-09 /pmc/articles/PMC8350217/ /pubmed/34381648 http://dx.doi.org/10.7759/cureus.16288 Text en Copyright © 2021, Kumari et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Kumari, Naina
Khan, Anoosha
Shaikh, Usman
Lobes, Kimberly
Kumar, Deepak
Suman, FNU
Bhutto, Naila S
Anees, Faryal
Shahid, Simra
Rizwan, Amber
Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
title Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
title_full Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
title_fullStr Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
title_full_unstemmed Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
title_short Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes
title_sort comparison of testosterone levels in patients with and without type 2 diabetes
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350217/
https://www.ncbi.nlm.nih.gov/pubmed/34381648
http://dx.doi.org/10.7759/cureus.16288
work_keys_str_mv AT kumarinaina comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT khananoosha comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT shaikhusman comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT lobeskimberly comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT kumardeepak comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT sumanfnu comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT bhuttonailas comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT aneesfaryal comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT shahidsimra comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes
AT rizwanamber comparisonoftestosteronelevelsinpatientswithandwithouttype2diabetes