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The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis

Innate lymphoid cells (ILCs) are a recently discovered lymphocyte population with high cytokine productive capacity. Type-2 ILCs (ILC2s) are the most studied, and they exert a rapid type-2 immune response to eliminate helminth infections. Massive and sustainable ILC2 activation induces allergic tiss...

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Autores principales: Nagashima, Ryuichi, Iyoda, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350317/
https://www.ncbi.nlm.nih.gov/pubmed/34381446
http://dx.doi.org/10.3389/fimmu.2021.688647
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author Nagashima, Ryuichi
Iyoda, Masayuki
author_facet Nagashima, Ryuichi
Iyoda, Masayuki
author_sort Nagashima, Ryuichi
collection PubMed
description Innate lymphoid cells (ILCs) are a recently discovered lymphocyte population with high cytokine productive capacity. Type-2 ILCs (ILC2s) are the most studied, and they exert a rapid type-2 immune response to eliminate helminth infections. Massive and sustainable ILC2 activation induces allergic tissue inflammation, so it is important to maintain correct ILC2 activity for immune homeostasis. The ILC2-activating cytokine IL-33 is released from epithelial cells upon tissue damage, and it is upregulated in various kidney disease mouse models and in kidney disease patients. Various kidney diseases eventually lead to renal fibrosis, which is a common pathway leading to end-stage renal disease and is a chronic kidney disease symptom. The progression of renal fibrosis is affected by the innate immune system, including renal-resident ILC2s; however, the roles of ILC2s in renal fibrosis are not well understood. In this review, we summarize renal ILC2 function and characterization in various kidney diseases and highlight the known and potential contributions of ILC2s to kidney fibrosis.
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spelling pubmed-83503172021-08-10 The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis Nagashima, Ryuichi Iyoda, Masayuki Front Immunol Immunology Innate lymphoid cells (ILCs) are a recently discovered lymphocyte population with high cytokine productive capacity. Type-2 ILCs (ILC2s) are the most studied, and they exert a rapid type-2 immune response to eliminate helminth infections. Massive and sustainable ILC2 activation induces allergic tissue inflammation, so it is important to maintain correct ILC2 activity for immune homeostasis. The ILC2-activating cytokine IL-33 is released from epithelial cells upon tissue damage, and it is upregulated in various kidney disease mouse models and in kidney disease patients. Various kidney diseases eventually lead to renal fibrosis, which is a common pathway leading to end-stage renal disease and is a chronic kidney disease symptom. The progression of renal fibrosis is affected by the innate immune system, including renal-resident ILC2s; however, the roles of ILC2s in renal fibrosis are not well understood. In this review, we summarize renal ILC2 function and characterization in various kidney diseases and highlight the known and potential contributions of ILC2s to kidney fibrosis. Frontiers Media S.A. 2021-07-26 /pmc/articles/PMC8350317/ /pubmed/34381446 http://dx.doi.org/10.3389/fimmu.2021.688647 Text en Copyright © 2021 Nagashima and Iyoda https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Nagashima, Ryuichi
Iyoda, Masayuki
The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
title The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
title_full The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
title_fullStr The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
title_full_unstemmed The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
title_short The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
title_sort roles of kidney-resident ilc2 in renal inflammation and fibrosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350317/
https://www.ncbi.nlm.nih.gov/pubmed/34381446
http://dx.doi.org/10.3389/fimmu.2021.688647
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