Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report

• Clear cell adenocarcinoma of the lower urinary tract is rare and poses diagnostic challenge. • GATA3, which is frequently expressed in urothelial carcinoma, can be expressed in clear cell adenocarcinoma. • ARID1A, PBRM1, ERBB4, and SMARCA4 mutations were identified in the current CASE. • Molecular...

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Autores principales: Abdelwahab, Hala, Friedman, Derek, Lightle, Andrea, Mian, Badar, Fisher, Hugh, Akgul, Mahmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350364/
https://www.ncbi.nlm.nih.gov/pubmed/34401347
http://dx.doi.org/10.1016/j.eucr.2021.101793
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author Abdelwahab, Hala
Friedman, Derek
Lightle, Andrea
Mian, Badar
Fisher, Hugh
Akgul, Mahmut
author_facet Abdelwahab, Hala
Friedman, Derek
Lightle, Andrea
Mian, Badar
Fisher, Hugh
Akgul, Mahmut
author_sort Abdelwahab, Hala
collection PubMed
description • Clear cell adenocarcinoma of the lower urinary tract is rare and poses diagnostic challenge. • GATA3, which is frequently expressed in urothelial carcinoma, can be expressed in clear cell adenocarcinoma. • ARID1A, PBRM1, ERBB4, and SMARCA4 mutations were identified in the current CASE. • Molecular studies may aid in the diagnosis, and optimal treatment decision-making process.
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spelling pubmed-83503642021-08-15 Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report Abdelwahab, Hala Friedman, Derek Lightle, Andrea Mian, Badar Fisher, Hugh Akgul, Mahmut Urol Case Rep Oncology • Clear cell adenocarcinoma of the lower urinary tract is rare and poses diagnostic challenge. • GATA3, which is frequently expressed in urothelial carcinoma, can be expressed in clear cell adenocarcinoma. • ARID1A, PBRM1, ERBB4, and SMARCA4 mutations were identified in the current CASE. • Molecular studies may aid in the diagnosis, and optimal treatment decision-making process. Elsevier 2021-08-01 /pmc/articles/PMC8350364/ /pubmed/34401347 http://dx.doi.org/10.1016/j.eucr.2021.101793 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Abdelwahab, Hala
Friedman, Derek
Lightle, Andrea
Mian, Badar
Fisher, Hugh
Akgul, Mahmut
Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report
title Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report
title_full Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report
title_fullStr Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report
title_full_unstemmed Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report
title_short Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report
title_sort distinct mutational status in gata3-positive clear cell adenocarcinoma of the urinary tract: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350364/
https://www.ncbi.nlm.nih.gov/pubmed/34401347
http://dx.doi.org/10.1016/j.eucr.2021.101793
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