Chaperonin Abundance Enhances Bacterial Fitness

The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance conf...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, C. M. Santosh, Chugh, Kritika, Dutta, Anirban, Mahamkali, Vishnuvardhan, Bose, Tungadri, Mande, Sharmila S., Mande, Shekhar C., Lund, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350394/
https://www.ncbi.nlm.nih.gov/pubmed/34381811
http://dx.doi.org/10.3389/fmolb.2021.669996
Descripción
Sumario:The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance confers 1) an ability to tolerate higher temperatures, 2) improved cellular fitness, and 3) enhanced folding of metabolic enzymes, which is expected to lead to enhanced energy harvesting potential.

Ejemplares similares