Chaperonin Abundance Enhances Bacterial Fitness

The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance conf...

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Autores principales: Kumar, C. M. Santosh, Chugh, Kritika, Dutta, Anirban, Mahamkali, Vishnuvardhan, Bose, Tungadri, Mande, Sharmila S., Mande, Shekhar C., Lund, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350394/
https://www.ncbi.nlm.nih.gov/pubmed/34381811
http://dx.doi.org/10.3389/fmolb.2021.669996
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author Kumar, C. M. Santosh
Chugh, Kritika
Dutta, Anirban
Mahamkali, Vishnuvardhan
Bose, Tungadri
Mande, Sharmila S.
Mande, Shekhar C.
Lund, Peter A.
author_facet Kumar, C. M. Santosh
Chugh, Kritika
Dutta, Anirban
Mahamkali, Vishnuvardhan
Bose, Tungadri
Mande, Sharmila S.
Mande, Shekhar C.
Lund, Peter A.
author_sort Kumar, C. M. Santosh
collection PubMed
description The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance confers 1) an ability to tolerate higher temperatures, 2) improved cellular fitness, and 3) enhanced folding of metabolic enzymes, which is expected to lead to enhanced energy harvesting potential.
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spelling pubmed-83503942021-08-10 Chaperonin Abundance Enhances Bacterial Fitness Kumar, C. M. Santosh Chugh, Kritika Dutta, Anirban Mahamkali, Vishnuvardhan Bose, Tungadri Mande, Sharmila S. Mande, Shekhar C. Lund, Peter A. Front Mol Biosci Molecular Biosciences The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in Escherichia coli. We demonstrate that chaperonin abundance confers 1) an ability to tolerate higher temperatures, 2) improved cellular fitness, and 3) enhanced folding of metabolic enzymes, which is expected to lead to enhanced energy harvesting potential. Frontiers Media S.A. 2021-07-26 /pmc/articles/PMC8350394/ /pubmed/34381811 http://dx.doi.org/10.3389/fmolb.2021.669996 Text en Copyright © 2021 Kumar, Chugh, Dutta, Mahamkali, Bose, Mande, Mande and Lund. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Kumar, C. M. Santosh
Chugh, Kritika
Dutta, Anirban
Mahamkali, Vishnuvardhan
Bose, Tungadri
Mande, Sharmila S.
Mande, Shekhar C.
Lund, Peter A.
Chaperonin Abundance Enhances Bacterial Fitness
title Chaperonin Abundance Enhances Bacterial Fitness
title_full Chaperonin Abundance Enhances Bacterial Fitness
title_fullStr Chaperonin Abundance Enhances Bacterial Fitness
title_full_unstemmed Chaperonin Abundance Enhances Bacterial Fitness
title_short Chaperonin Abundance Enhances Bacterial Fitness
title_sort chaperonin abundance enhances bacterial fitness
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350394/
https://www.ncbi.nlm.nih.gov/pubmed/34381811
http://dx.doi.org/10.3389/fmolb.2021.669996
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