Hsa-miR-4277 Decelerates the Metabolism or Clearance of Sorafenib in HCC Cells and Enhances the Sensitivity of HCC Cells to Sorafenib by Targeting cyp3a4

Increasing evidence has shown that the metabolism and clearance of molecular targeted agents, such as sorafenib, plays an important role in mediating the resistance of HCC cells to these agents. Metabolism of sorafenib is performed by oxidative metabolism, which is initially mediated by CYP3A4. Thus...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xi, Sun, Huiwei, Jiang, Qiyu, Chai, Yantao, Li, Xiaojuan, Wang, Zhijie, Zhu, Bing, You, Shaoli, Li, Boan, Hao, Junfeng, Xin, Shaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350395/
https://www.ncbi.nlm.nih.gov/pubmed/34381736
http://dx.doi.org/10.3389/fonc.2021.735447

Ejemplares similares

Ejemplares similares