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Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

OBJECTIVE: Type II nuclear hormone receptors, including farnesoid X receptors (FXR), liver X receptors (LXR), and peroxisome proliferator-activated receptors (PPAR), which serve as drug targets for metabolic diseases, are permanently positioned in the nucleus and thought to be bound to DNA regardles...

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Detalles Bibliográficos
Autores principales:	Kain, Jessica, Wei, Xiaolong, Reddy, Nihal A., Price, Andrew J., Woods, Claire, Bochkis, Irina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350412/ https://www.ncbi.nlm.nih.gov/pubmed/34246806 http://dx.doi.org/10.1016/j.molmet.2021.101291

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