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Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19

The COVID-19 outbreak has called for renewed attention to the need for sound statistical analyses to monitor mortality patterns and trends over time. Excess mortality has been suggested as the most appropriate indicator to measure the overall burden of the pandemic in terms of mortality. As such, ex...

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Autores principales: Vanella, Patrizio, Basellini, Ugofilippo, Lange, Berit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350559/
https://www.ncbi.nlm.nih.gov/pubmed/34393261
http://dx.doi.org/10.1186/s41118-021-00123-9
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author Vanella, Patrizio
Basellini, Ugofilippo
Lange, Berit
author_facet Vanella, Patrizio
Basellini, Ugofilippo
Lange, Berit
author_sort Vanella, Patrizio
collection PubMed
description The COVID-19 outbreak has called for renewed attention to the need for sound statistical analyses to monitor mortality patterns and trends over time. Excess mortality has been suggested as the most appropriate indicator to measure the overall burden of the pandemic in terms of mortality. As such, excess mortality has received considerable interest since the outbreak of COVID-19 began. Previous approaches to estimate excess mortality are somewhat limited, as they do not include sufficiently long-term trends, correlations among different demographic and geographic groups, or autocorrelations in the mortality time series. This might lead to biased estimates of excess mortality, as random mortality fluctuations may be misinterpreted as excess mortality. We propose a novel approach that overcomes the named limitations and draws a more realistic picture of excess mortality. Our approach is based on an established forecasting model that is used in demography, namely, the Lee-Carter model. We illustrate our approach by using the weekly age- and sex-specific mortality data for 19 countries and the current COVID-19 pandemic as a case study. Our findings show evidence of considerable excess mortality during 2020 in Europe, which affects different countries, age, and sex groups heterogeneously. Our proposed model can be applied to future pandemics as well as to monitor excess mortality from specific causes of death.
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spelling pubmed-83505592021-08-09 Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19 Vanella, Patrizio Basellini, Ugofilippo Lange, Berit Genus Original Article The COVID-19 outbreak has called for renewed attention to the need for sound statistical analyses to monitor mortality patterns and trends over time. Excess mortality has been suggested as the most appropriate indicator to measure the overall burden of the pandemic in terms of mortality. As such, excess mortality has received considerable interest since the outbreak of COVID-19 began. Previous approaches to estimate excess mortality are somewhat limited, as they do not include sufficiently long-term trends, correlations among different demographic and geographic groups, or autocorrelations in the mortality time series. This might lead to biased estimates of excess mortality, as random mortality fluctuations may be misinterpreted as excess mortality. We propose a novel approach that overcomes the named limitations and draws a more realistic picture of excess mortality. Our approach is based on an established forecasting model that is used in demography, namely, the Lee-Carter model. We illustrate our approach by using the weekly age- and sex-specific mortality data for 19 countries and the current COVID-19 pandemic as a case study. Our findings show evidence of considerable excess mortality during 2020 in Europe, which affects different countries, age, and sex groups heterogeneously. Our proposed model can be applied to future pandemics as well as to monitor excess mortality from specific causes of death. Springer International Publishing 2021-08-09 2021 /pmc/articles/PMC8350559/ /pubmed/34393261 http://dx.doi.org/10.1186/s41118-021-00123-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Vanella, Patrizio
Basellini, Ugofilippo
Lange, Berit
Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19
title Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19
title_full Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19
title_fullStr Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19
title_full_unstemmed Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19
title_short Assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of COVID-19
title_sort assessing excess mortality in times of pandemics based on principal component analysis of weekly mortality data—the case of covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350559/
https://www.ncbi.nlm.nih.gov/pubmed/34393261
http://dx.doi.org/10.1186/s41118-021-00123-9
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