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METTL3-induced UCK2 m(6)A hypermethylation promotes melanoma cancer cell metastasis via the WNT/β-catenin pathway

BACKGROUND: Melanoma is a highly aggressive, malignant skin tumor with a statistically high mortality rate. N6-methyladenosine (m(6)A) modification is involved in a variety of biological processes, including tumorigenesis. m(6)A modifications regulate the fate and functions of RNA, such as mRNA stab...

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Detalles Bibliográficos
Autores principales: Wu, Hao, Xu, Haochao, Jia, Dongdong, Li, Tao, Xia, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350655/
https://www.ncbi.nlm.nih.gov/pubmed/34430596
http://dx.doi.org/10.21037/atm-21-2906