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Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging

BACKGROUND: Exposure to ultraviolet (UV) radiation (UVB and UVA) is the most well-known extrinsic factor that induces skin aging. Fucoidan has been shown to possess antiphotoaging effects against UV irradiation and can be used as an ingredient in the pharmaceutical industry. The present study evalua...

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Autores principales: Jing, Rongrong, Guo, Keke, Zhong, Yulan, Wang, Lusheng, Zhao, Jungang, Gao, Bingyan, Ye, Ziyi, Chen, Yu, Li, Xuenan, Xu, Nuo, Xuan, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350689/
https://www.ncbi.nlm.nih.gov/pubmed/34430626
http://dx.doi.org/10.21037/atm-21-3668
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author Jing, Rongrong
Guo, Keke
Zhong, Yulan
Wang, Lusheng
Zhao, Jungang
Gao, Bingyan
Ye, Ziyi
Chen, Yu
Li, Xuenan
Xu, Nuo
Xuan, Xuan
author_facet Jing, Rongrong
Guo, Keke
Zhong, Yulan
Wang, Lusheng
Zhao, Jungang
Gao, Bingyan
Ye, Ziyi
Chen, Yu
Li, Xuenan
Xu, Nuo
Xuan, Xuan
author_sort Jing, Rongrong
collection PubMed
description BACKGROUND: Exposure to ultraviolet (UV) radiation (UVB and UVA) is the most well-known extrinsic factor that induces skin aging. Fucoidan has been shown to possess antiphotoaging effects against UV irradiation and can be used as an ingredient in the pharmaceutical industry. The present study evaluated the photoprotective effect of fucoidan purified from Undaria pinnatifida (UPF) on UV-induced skin photoaging and explored its potential molecular mechanism. METHODS: To evaluate the effect of UPF on UV-induced skin aging, HaCaT cells and HFF-1 cells were pretreated with or without UPF and then exposed to UVB and UVA radiation, respectively, and the levels of cellular senescence, reactive oxygen species (ROS) production and mitochondrial dysfunction were evaluated. The mitochondrial ROS (mROS) was stained through MitoSOX, and the confocal microscope was used to capture the images. For further exploration of AMPK/SIRT-1/PGC-1α signaling, western blot was employed. RESULTS: The results demonstrated that pretreatment of HaCaT and HFF-1 cells with UPF ameliorated cellular senescence, ROS and mROS overproduction, and mitochondrial dysfunction caused by UV exposure. This research also revealed that UPF could activate the AMPK/SIRT-1/PGC-1α signaling pathway to promote mitochondrial biogenesis. CONCLUSIONS: UPF can ameliorate UV-induced skin photoaging through inhibition of ROS production via the alleviation of mitochondrial dysfunction by regulating the SIRT-1/PGC-1α signaling pathway.
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spelling pubmed-83506892021-08-23 Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging Jing, Rongrong Guo, Keke Zhong, Yulan Wang, Lusheng Zhao, Jungang Gao, Bingyan Ye, Ziyi Chen, Yu Li, Xuenan Xu, Nuo Xuan, Xuan Ann Transl Med Original Article BACKGROUND: Exposure to ultraviolet (UV) radiation (UVB and UVA) is the most well-known extrinsic factor that induces skin aging. Fucoidan has been shown to possess antiphotoaging effects against UV irradiation and can be used as an ingredient in the pharmaceutical industry. The present study evaluated the photoprotective effect of fucoidan purified from Undaria pinnatifida (UPF) on UV-induced skin photoaging and explored its potential molecular mechanism. METHODS: To evaluate the effect of UPF on UV-induced skin aging, HaCaT cells and HFF-1 cells were pretreated with or without UPF and then exposed to UVB and UVA radiation, respectively, and the levels of cellular senescence, reactive oxygen species (ROS) production and mitochondrial dysfunction were evaluated. The mitochondrial ROS (mROS) was stained through MitoSOX, and the confocal microscope was used to capture the images. For further exploration of AMPK/SIRT-1/PGC-1α signaling, western blot was employed. RESULTS: The results demonstrated that pretreatment of HaCaT and HFF-1 cells with UPF ameliorated cellular senescence, ROS and mROS overproduction, and mitochondrial dysfunction caused by UV exposure. This research also revealed that UPF could activate the AMPK/SIRT-1/PGC-1α signaling pathway to promote mitochondrial biogenesis. CONCLUSIONS: UPF can ameliorate UV-induced skin photoaging through inhibition of ROS production via the alleviation of mitochondrial dysfunction by regulating the SIRT-1/PGC-1α signaling pathway. AME Publishing Company 2021-07 /pmc/articles/PMC8350689/ /pubmed/34430626 http://dx.doi.org/10.21037/atm-21-3668 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Jing, Rongrong
Guo, Keke
Zhong, Yulan
Wang, Lusheng
Zhao, Jungang
Gao, Bingyan
Ye, Ziyi
Chen, Yu
Li, Xuenan
Xu, Nuo
Xuan, Xuan
Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging
title Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging
title_full Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging
title_fullStr Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging
title_full_unstemmed Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging
title_short Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging
title_sort protective effects of fucoidan purified from undaria pinnatifida against uv-irradiated skin photoaging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350689/
https://www.ncbi.nlm.nih.gov/pubmed/34430626
http://dx.doi.org/10.21037/atm-21-3668
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