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Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series

BACKGROUND: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation. CASE: Thi...

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Autores principales: Eftekhar, Maryam, Mohammadi, Banafsheh, Tabibnejad, Nasim, Razi, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350847/
https://www.ncbi.nlm.nih.gov/pubmed/34401651
http://dx.doi.org/10.18502/ijrm.v19i6.9378
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author Eftekhar, Maryam
Mohammadi, Banafsheh
Tabibnejad, Nasim
Razi, Mohammad Hossein
author_facet Eftekhar, Maryam
Mohammadi, Banafsheh
Tabibnejad, Nasim
Razi, Mohammad Hossein
author_sort Eftekhar, Maryam
collection PubMed
description BACKGROUND: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation. CASE: This case-series presents pregnancies resulting from initially scheduled conventional in vitro fertilization which led to arrested cycles because of resistant ovary syndrome. The protocol was changed to early oocyte triggering for 15 women due to the small follicles [Formula: see text] 12 mm in diameter on day 15 after stimulation with high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal vesicle and metaphase I oocytes that were retrieved from follicles were matured in vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical pregnancy out of which no abortion occurred. Therefore, we reported a 30.76% singleton ongoing pregnancy. CONCLUSION: It seems that early oocyte triggering followed by in vitro maturation may be considered as a good modality in women experiencing follicular resistance to gonadotropins. These cycles can be rescued from cancellation with satisfactory clinical outcomes.
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spelling pubmed-83508472021-08-15 Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series Eftekhar, Maryam Mohammadi, Banafsheh Tabibnejad, Nasim Razi, Mohammad Hossein Int J Reprod Biomed Case Series BACKGROUND: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation. CASE: This case-series presents pregnancies resulting from initially scheduled conventional in vitro fertilization which led to arrested cycles because of resistant ovary syndrome. The protocol was changed to early oocyte triggering for 15 women due to the small follicles [Formula: see text] 12 mm in diameter on day 15 after stimulation with high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal vesicle and metaphase I oocytes that were retrieved from follicles were matured in vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical pregnancy out of which no abortion occurred. Therefore, we reported a 30.76% singleton ongoing pregnancy. CONCLUSION: It seems that early oocyte triggering followed by in vitro maturation may be considered as a good modality in women experiencing follicular resistance to gonadotropins. These cycles can be rescued from cancellation with satisfactory clinical outcomes. Knowledge E 2021-07-27 /pmc/articles/PMC8350847/ /pubmed/34401651 http://dx.doi.org/10.18502/ijrm.v19i6.9378 Text en Copyright © 2021 Eftekhar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Eftekhar, Maryam
Mohammadi, Banafsheh
Tabibnejad, Nasim
Razi, Mohammad Hossein
Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
title Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
title_full Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
title_fullStr Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
title_full_unstemmed Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
title_short Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
title_sort early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: a case-series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350847/
https://www.ncbi.nlm.nih.gov/pubmed/34401651
http://dx.doi.org/10.18502/ijrm.v19i6.9378
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