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Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming
Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immun...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350890/ https://www.ncbi.nlm.nih.gov/pubmed/34151532 http://dx.doi.org/10.15252/emmm.202114323 |
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author | Hirschberger, Simon Strauß, Gabriele Effinger, David Marstaller, Xaver Ferstl, Alicia Müller, Martin B Wu, Tingting Hübner, Max Rahmel, Tim Mascolo, Hannah Exner, Nicole Heß, Julia Kreth, Friedrich W Unger, Kristian Kreth, Simone |
author_facet | Hirschberger, Simon Strauß, Gabriele Effinger, David Marstaller, Xaver Ferstl, Alicia Müller, Martin B Wu, Tingting Hübner, Max Rahmel, Tim Mascolo, Hannah Exner, Nicole Heß, Julia Kreth, Friedrich W Unger, Kristian Kreth, Simone |
author_sort | Hirschberger, Simon |
collection | PubMed |
description | Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4(+), CD8(+), and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required. |
format | Online Article Text |
id | pubmed-8350890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83508902021-08-15 Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming Hirschberger, Simon Strauß, Gabriele Effinger, David Marstaller, Xaver Ferstl, Alicia Müller, Martin B Wu, Tingting Hübner, Max Rahmel, Tim Mascolo, Hannah Exner, Nicole Heß, Julia Kreth, Friedrich W Unger, Kristian Kreth, Simone EMBO Mol Med Articles Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as alternative energy substrates. There are as yet unproven assumptions that ketone bodies positively affect human immunity. We have investigated this topic in an in vitro model using primary human T cells and in an immuno‐nutritional intervention study enrolling healthy volunteers. We show that ketone bodies profoundly impact human T‐cell responses. CD4(+), CD8(+), and regulatory T‐cell capacity were markedly enhanced, and T memory cell formation was augmented. RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. This confers superior respiratory reserve, cellular energy supply, and reactive oxygen species signaling. Our data suggest a very‐low‐carbohydrate diet as a clinical tool to improve human T‐cell immunity. Rethinking the value of nutrition and dietary interventions in modern medicine is required. John Wiley and Sons Inc. 2021-06-21 2021-08-09 /pmc/articles/PMC8350890/ /pubmed/34151532 http://dx.doi.org/10.15252/emmm.202114323 Text en © 2021 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Hirschberger, Simon Strauß, Gabriele Effinger, David Marstaller, Xaver Ferstl, Alicia Müller, Martin B Wu, Tingting Hübner, Max Rahmel, Tim Mascolo, Hannah Exner, Nicole Heß, Julia Kreth, Friedrich W Unger, Kristian Kreth, Simone Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
title | Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
title_full | Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
title_fullStr | Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
title_full_unstemmed | Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
title_short | Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming |
title_sort | very‐low‐carbohydrate diet enhances human t‐cell immunity through immunometabolic reprogramming |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350890/ https://www.ncbi.nlm.nih.gov/pubmed/34151532 http://dx.doi.org/10.15252/emmm.202114323 |
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