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Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity

Ceramide‐induced mitochondrial fission drives high‐fat diet (HFD)‐induced obesity. However, molecules targeting mitochondrial dynamics have shown limited benefits in murine obesity models. Here, we reveal that these compounds are either unable to block ceramide‐induced mitochondrial fission or requi...

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Detalles Bibliográficos
Autores principales:	Jayashankar, Vaishali, Selwan, Elizabeth, Hancock, Sarah E, Verlande, Amandine, Goodson, Maggie O, Eckenstein, Kazumi H, Milinkeviciute, Giedre, Hoover, Brianna M, Chen, Bin, Fleischman, Angela G, Cramer, Karina S, Hanessian, Stephen, Masri, Selma, Turner, Nigel, Edinger, Aimee L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350895/ https://www.ncbi.nlm.nih.gov/pubmed/34231322 http://dx.doi.org/10.15252/emmm.202013086

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