Cargando…

Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family

Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of various cell-to-cell communication strategies...

Descripción completa

Detalles Bibliográficos
Autores principales: Pasqua, Martina, Bonaccorsi di Patti, Maria Carmela, Fanelli, Giulia, Utsumi, Ryutaro, Eguchi, Yoko, Trirocco, Rita, Prosseda, Gianni, Grossi, Milena, Colonna, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350985/
https://www.ncbi.nlm.nih.gov/pubmed/34381818
http://dx.doi.org/10.3389/fmolb.2021.723274
_version_ 1783735885275070464
author Pasqua, Martina
Bonaccorsi di Patti, Maria Carmela
Fanelli, Giulia
Utsumi, Ryutaro
Eguchi, Yoko
Trirocco, Rita
Prosseda, Gianni
Grossi, Milena
Colonna, Bianca
author_facet Pasqua, Martina
Bonaccorsi di Patti, Maria Carmela
Fanelli, Giulia
Utsumi, Ryutaro
Eguchi, Yoko
Trirocco, Rita
Prosseda, Gianni
Grossi, Milena
Colonna, Bianca
author_sort Pasqua, Martina
collection PubMed
description Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of various cell-to-cell communication strategies. The capability of the bacterial cells to rapidly and co-ordinately set up an interplay with the host cells and/or with other bacteria facilitates their survival in the new niche. Efflux pumps are ubiquitous transmembrane transporters, able to extrude a large set of different molecules. They are strongly implicated in antibiotic resistance since they are able to efficiently expel most of the clinically relevant antibiotics from the bacterial cytoplasm. Besides antibiotic resistance, multidrug efflux pumps take part in several important processes of bacterial cell physiology, including cell to cell communication, and contribute to increase the virulence potential of several bacterial pathogens. Here, we focus on the structural and functional role of multidrug efflux pumps belonging to the Major Facilitator Superfamily (MFS), the largest family of transporters, highlighting their involvement in the colonization of host cells, in virulence and in biofilm formation. We will offer an overview on how MFS multidrug transporters contribute to bacterial survival, adaptation and pathogenicity through the export of diverse molecules. This will be done by presenting the functions of several relevant MFS multidrug efflux pumps in human life-threatening bacterial pathogens as Staphylococcus aureus, Listeria monocytogenes, Klebsiella pneumoniae, Shigella/E. coli, Acinetobacter baumannii.
format Online
Article
Text
id pubmed-8350985
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83509852021-08-10 Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family Pasqua, Martina Bonaccorsi di Patti, Maria Carmela Fanelli, Giulia Utsumi, Ryutaro Eguchi, Yoko Trirocco, Rita Prosseda, Gianni Grossi, Milena Colonna, Bianca Front Mol Biosci Molecular Biosciences Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of various cell-to-cell communication strategies. The capability of the bacterial cells to rapidly and co-ordinately set up an interplay with the host cells and/or with other bacteria facilitates their survival in the new niche. Efflux pumps are ubiquitous transmembrane transporters, able to extrude a large set of different molecules. They are strongly implicated in antibiotic resistance since they are able to efficiently expel most of the clinically relevant antibiotics from the bacterial cytoplasm. Besides antibiotic resistance, multidrug efflux pumps take part in several important processes of bacterial cell physiology, including cell to cell communication, and contribute to increase the virulence potential of several bacterial pathogens. Here, we focus on the structural and functional role of multidrug efflux pumps belonging to the Major Facilitator Superfamily (MFS), the largest family of transporters, highlighting their involvement in the colonization of host cells, in virulence and in biofilm formation. We will offer an overview on how MFS multidrug transporters contribute to bacterial survival, adaptation and pathogenicity through the export of diverse molecules. This will be done by presenting the functions of several relevant MFS multidrug efflux pumps in human life-threatening bacterial pathogens as Staphylococcus aureus, Listeria monocytogenes, Klebsiella pneumoniae, Shigella/E. coli, Acinetobacter baumannii. Frontiers Media S.A. 2021-07-26 /pmc/articles/PMC8350985/ /pubmed/34381818 http://dx.doi.org/10.3389/fmolb.2021.723274 Text en Copyright © 2021 Pasqua, Bonaccorsi di Patti, Fanelli, Utsumi, Eguchi, Trirocco, Prosseda, Grossi and Colonna. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Pasqua, Martina
Bonaccorsi di Patti, Maria Carmela
Fanelli, Giulia
Utsumi, Ryutaro
Eguchi, Yoko
Trirocco, Rita
Prosseda, Gianni
Grossi, Milena
Colonna, Bianca
Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
title Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
title_full Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
title_fullStr Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
title_full_unstemmed Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
title_short Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
title_sort host - bacterial pathogen communication: the wily role of the multidrug efflux pumps of the mfs family
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350985/
https://www.ncbi.nlm.nih.gov/pubmed/34381818
http://dx.doi.org/10.3389/fmolb.2021.723274
work_keys_str_mv AT pasquamartina hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT bonaccorsidipattimariacarmela hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT fanelligiulia hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT utsumiryutaro hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT eguchiyoko hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT triroccorita hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT prossedagianni hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT grossimilena hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily
AT colonnabianca hostbacterialpathogencommunicationthewilyroleofthemultidrugeffluxpumpsofthemfsfamily