Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

In present investigation, AND-2-HyP-β-CYD (Andrographolide-2-Hydroxypropyl-β-cyclodextrin) complex was synthesized and characterized for antiviral and pharmacokinetic profile. The linear host-guest relation suggested synthesis of a 1:1 complex of AND with 2-HyP-β-CYD by inclusion mode. The Kc, stabi...

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Detalles Bibliográficos
Autores principales: Singh, Shashi Chandrama, Khatri, Dharmendra Kumar, Singh, Kulbhaskar, Kanchupalli, Vinay Kumar, Madan, Jitender, Singh, Shashi Bala, Singh, Harshpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351079/
https://www.ncbi.nlm.nih.gov/pubmed/34395929
http://dx.doi.org/10.1016/j.heliyon.2021.e07741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351079/
https://www.ncbi.nlm.nih.gov/pubmed/34395929
http://dx.doi.org/10.1016/j.heliyon.2021.e07741

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