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Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

In present investigation, AND-2-HyP-β-CYD (Andrographolide-2-Hydroxypropyl-β-cyclodextrin) complex was synthesized and characterized for antiviral and pharmacokinetic profile. The linear host-guest relation suggested synthesis of a 1:1 complex of AND with 2-HyP-β-CYD by inclusion mode. The Kc, stabi...

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Detalles Bibliográficos
Autores principales:	Singh, Shashi Chandrama, Khatri, Dharmendra Kumar, Singh, Kulbhaskar, Kanchupalli, Vinay Kumar, Madan, Jitender, Singh, Shashi Bala, Singh, Harshpal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351079/ https://www.ncbi.nlm.nih.gov/pubmed/34395929 http://dx.doi.org/10.1016/j.heliyon.2021.e07741

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