Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of human diseases, especially cancers. SBF2-AS1, a newly identified long non-coding RNA, has bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Qian, Lou, Jun, Cai, Ruyun, Han, Weidong, Pan, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351094/
https://www.ncbi.nlm.nih.gov/pubmed/34372871
http://dx.doi.org/10.1186/s12935-021-02123-3
_version_ 1783735899021901824
author Lu, Qian
Lou, Jun
Cai, Ruyun
Han, Weidong
Pan, Hongming
author_facet Lu, Qian
Lou, Jun
Cai, Ruyun
Han, Weidong
Pan, Hongming
author_sort Lu, Qian
collection PubMed
description Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of human diseases, especially cancers. SBF2-AS1, a newly identified long non-coding RNA, has been verified to be highly expressed in diversiform cancers, and is involved in processes promoting tumorigenesis, tumor progression and tumor metastasis. Moreover, upregulation of SBF2-AS1 expression was significantly related to disadvantageous clinicopathologic characteristics and indicated poor prognosis. In this review, we comprehensively summarize the up-to-date knowledge of the detailed mechanisms and underlying functions of SBF2-AS1 in diverse cancer types, highlighting the potential of SBF2-AS1 as a diagnostic and prognostic biomarker and even a therapeutic target.
format Online
Article
Text
id pubmed-8351094
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-83510942021-08-09 Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers Lu, Qian Lou, Jun Cai, Ruyun Han, Weidong Pan, Hongming Cancer Cell Int Review Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of human diseases, especially cancers. SBF2-AS1, a newly identified long non-coding RNA, has been verified to be highly expressed in diversiform cancers, and is involved in processes promoting tumorigenesis, tumor progression and tumor metastasis. Moreover, upregulation of SBF2-AS1 expression was significantly related to disadvantageous clinicopathologic characteristics and indicated poor prognosis. In this review, we comprehensively summarize the up-to-date knowledge of the detailed mechanisms and underlying functions of SBF2-AS1 in diverse cancer types, highlighting the potential of SBF2-AS1 as a diagnostic and prognostic biomarker and even a therapeutic target. BioMed Central 2021-08-09 /pmc/articles/PMC8351094/ /pubmed/34372871 http://dx.doi.org/10.1186/s12935-021-02123-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lu, Qian
Lou, Jun
Cai, Ruyun
Han, Weidong
Pan, Hongming
Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
title Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
title_full Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
title_fullStr Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
title_full_unstemmed Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
title_short Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
title_sort emerging roles of a pivotal lncrna sbf2-as1 in cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351094/
https://www.ncbi.nlm.nih.gov/pubmed/34372871
http://dx.doi.org/10.1186/s12935-021-02123-3
work_keys_str_mv AT luqian emergingrolesofapivotallncrnasbf2as1incancers
AT loujun emergingrolesofapivotallncrnasbf2as1incancers
AT cairuyun emergingrolesofapivotallncrnasbf2as1incancers
AT hanweidong emergingrolesofapivotallncrnasbf2as1incancers
AT panhongming emergingrolesofapivotallncrnasbf2as1incancers

Ejemplares similares