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BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis

Olfactory receptors (ORs), responsible for the sense of smell, play an essential role in physiological processes (even outside the nasal epithelium) and cancer. In breast cancer, however, the expression and role of ORs remain understudied. We examined the significance of ORs transcript abundance in...

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Autores principales: Li, Mao, Schweiger, Markus, Nakano, Ichiro, Ryan, Daniel, Carvalho, Litia, Tannous, Bakhos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351190/
http://dx.doi.org/10.1093/noajnl/vdab071.015
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author Li, Mao
Schweiger, Markus
Nakano, Ichiro
Ryan, Daniel
Carvalho, Litia
Tannous, Bakhos
author_facet Li, Mao
Schweiger, Markus
Nakano, Ichiro
Ryan, Daniel
Carvalho, Litia
Tannous, Bakhos
author_sort Li, Mao
collection PubMed
description Olfactory receptors (ORs), responsible for the sense of smell, play an essential role in physiological processes (even outside the nasal epithelium) and cancer. In breast cancer, however, the expression and role of ORs remain understudied. We examined the significance of ORs transcript abundance in breast cancer metastasis to different tissues including the brain, bone, and lung. While we found 20 OR genes to be differentially expressed in different metastasis versus primary tumor, OR5B21 displayed high relation with all metastases. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells in culture as well as metastasis to different organs including the brain, in vivo. On the other hand, overexpression of OR5B21 in the primary cells had the opposite effect. Mechanistically, OR5B21 was associated with epithelial to mesenchymal transition through STAT3/NFkB/CEBPβ signaling pathway. We propose OR5B21 (and potentially other ORs) as a novel oncogene contributing to breast cancer metastasis, and as a potential target for therapy.
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spelling pubmed-83511902021-08-09 BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis Li, Mao Schweiger, Markus Nakano, Ichiro Ryan, Daniel Carvalho, Litia Tannous, Bakhos Neurooncol Adv Supplement Abstracts Olfactory receptors (ORs), responsible for the sense of smell, play an essential role in physiological processes (even outside the nasal epithelium) and cancer. In breast cancer, however, the expression and role of ORs remain understudied. We examined the significance of ORs transcript abundance in breast cancer metastasis to different tissues including the brain, bone, and lung. While we found 20 OR genes to be differentially expressed in different metastasis versus primary tumor, OR5B21 displayed high relation with all metastases. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells in culture as well as metastasis to different organs including the brain, in vivo. On the other hand, overexpression of OR5B21 in the primary cells had the opposite effect. Mechanistically, OR5B21 was associated with epithelial to mesenchymal transition through STAT3/NFkB/CEBPβ signaling pathway. We propose OR5B21 (and potentially other ORs) as a novel oncogene contributing to breast cancer metastasis, and as a potential target for therapy. Oxford University Press 2021-08-09 /pmc/articles/PMC8351190/ http://dx.doi.org/10.1093/noajnl/vdab071.015 Text en © The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Abstracts
Li, Mao
Schweiger, Markus
Nakano, Ichiro
Ryan, Daniel
Carvalho, Litia
Tannous, Bakhos
BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis
title BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis
title_full BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis
title_fullStr BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis
title_full_unstemmed BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis
title_short BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis
title_sort bsci-16. olfactory receptor 5b21 drives breast cancer metastasis
topic Supplement Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351190/
http://dx.doi.org/10.1093/noajnl/vdab071.015
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